Abdul Aziz - Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
Imran Ahmad Khan - Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
Musaddique Hussain - Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan School of Pharmacy, The University of Faisalabad, Faisalabad, Pakistan
Muhammad Asif Raza - University Of Agriculture, Faisalabad (Sub campus Dera Ghazi Khan), Pakistan.

The methanolic leaf extract of Thuja occidentalis was evaluated for possible sedative activities in mice. Sedative activity was evaluated by using hole cross, open field, thiopental sodium-induced sleeping timeand elevated-plus maze (EPM) tests at 200mg/kg and 400 mg/kg. The extract decreased the locomotor activity of mice in hole cross, open field and EPM test and showed the remarkable results as compared to the standard at both mentioned doses. Moreover, the extractsignificantly minimized onset of sleep and maximized the duration of sleeping time when administered with thiopental sodium and statistically it was significant (p < 0.05).

Thuja occidentalis, Sedative, Thiopental sodium