Novel immunotherapeutic trimethyl Chitosan-recombinant protein Hp-Nap of helicobacter pylori Nanocomplex as Breast Cancer treatment

  • سال انتشار: 1393
  • محل انتشار: پنجمین کنگره بین المللی نانو و فناوری نانو (ICNN2014)
  • کد COI اختصاصی: ICNN05_769
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 521
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نویسندگان

Neda Soleimani

PhD student, Dept of Bacteriology, Student Research Committee, Faculty of Medical sciences, Tarbiat Modares University

Ashraf Mohabati Mobarez

Associate professor, Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University,Tehran, Iran.

چکیده

Breast cancer is one of the leading causes of death in women around the world with a very highdegree of mortality and morbidity. The Helicobacter pylori neutrophil-activating protein (HP-NAP)promotes their endothelial adhesion and the production of oxygen radicals and chemokines. HP-NAP is animmune modulator able to induce the expression of IL-12 and IL-23. Chitosan is biodegradable andbiocompatible component. It is low toxicity effect, so apply in drug delivery targets. The aim of studyisNovel immunotherapeutic Chitosan-recombinant protein Hp-Nap of helicobacter pylori Nanocomplex asBreast Cancer treatment. Chitosan Nanoparticles were produce. The size and morphology of thenanoparticles were investigated. recombinant HP-NAP Helicobacter pylori were produce.SDS-PAGEanalysis showed the expression of an approximately 20000 Dalton protein. DLS confirm size and zetapotential of the nanoparticle.Tunnel and flow cytometry confirm apoptosis.The complex has the potential toshift antigen-specific T-cell responses from a predominant Th2 to a polarized Th1 cytotoxic phenotype,characterized by high levels of interferon-γ and tumor necrosis factor-a production. HP-NAP may be a newtool for future therapeutic strategies aimed in cancer immunotherapy. Nanomaterials have been used toenable drug delivery with lower toxicity to healthy cells and enhanced drug delivery to tumor cells.Keywords: Breast cancer, Recombinant HP-NAP, Chitosan.

کلیدواژه ها

Breast cancer, Recombinant HP-NAP, Chitosan

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