Mechanical evaluationof poly (3-hydroxybutyrate)/bioactive glass nanocompositescaffoldfabricated by electrospinning for bone tissue engineering

  • سال انتشار: 1393
  • محل انتشار: پنجمین کنگره بین المللی نانو و فناوری نانو (ICNN2014)
  • کد COI اختصاصی: ICNN05_747
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 656
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نویسندگان

R Iron

Department of New Science and Technology Campus (Biomaterial Group), Semnan University, Semnan, Iran

M Mehdikhani-Nahrkhalaii

Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran

S Karbasi

Medical Physics and Biomedical Engineering Group, School of Medicine, Isfahan University of Medical Sciences(IUMS), Isfahan, Iran

چکیده

Recently, 3-D nanocomposite scaffolds have shown wide applications in bone tissue engineering forreplacement, regeneration and repair of damaged tissues. In this study, poly (3-hydroxybutyrate) (P3HB)/bioactiveglass (BG) nanocomposite scaffolds with 7.5, 10 and 15 wt% BG nanoparticles were prepared by electrospinningprocess. Scaffolds were characterized by scanning electron microscopy (SEM) and Fourier transform infraredspectroscopy (FTIR). Mechanical properties of the prepared scaffolds were determined by tensile test. BGnanoparticles showed agglomerate formation tendency in more than 10 wt%. SEM images proved interconnectedporous architecture of the scaffolds. FTIR analysis confirmed the interaction of P3HB and BG nanoparticles. Scaffoldscontaining 7.5 wt% of BG nanoparticles demonstrated highest tensile strength. In conclusion, electrospun P3HB/ (7.5wt%) BG nanocomposite scaffold could be used as a candidate for bone tissue engineering.

کلیدواژه ها

Bioactive Glass Nanoparticles; Poly (3-hydroxybutyrate); Tissue Engineering; Electrospinning; Nanocomposite Scaffold

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