Investigation of Effect of Various Drug Loading on Buprenorphine Hydrochloride release from In situ forming Systems based on PLGA polymers
عنوان مقاله: Investigation of Effect of Various Drug Loading on Buprenorphine Hydrochloride release from In situ forming Systems based on PLGA polymers
شناسه ملی مقاله: ICHEC15_615
منتشر شده در پانزدهمین کنگره ملی مهندسی شیمی ایران در سال 1393
شناسه ملی مقاله: ICHEC15_615
منتشر شده در پانزدهمین کنگره ملی مهندسی شیمی ایران در سال 1393
مشخصات نویسندگان مقاله:
Mahboobeh Hosseini - Iran polymer and petrochemical institute, Novel drug delivery systems department
Hamid Mobedi - Iran polymer and petrochemical institute, Novel drug delivery systems department
Ahmad Jamshidi - Iran polymer and petrochemical institute, Novel drug delivery systems department
خلاصه مقاله:
Mahboobeh Hosseini - Iran polymer and petrochemical institute, Novel drug delivery systems department
Hamid Mobedi - Iran polymer and petrochemical institute, Novel drug delivery systems department
Ahmad Jamshidi - Iran polymer and petrochemical institute, Novel drug delivery systems department
On the bases of the previous investigations on developing in situ forming sol-gel delivery system for some therapeutic agents, optimization of these systems for a sustained and prolonged delivery of buprenorphine in post treatment of narcotic addiction, controlling acute and chronic pains has been proposed. Different loadings of 15, 30, and 60 mg buprenorphine hydrochloride using Poly (D, L-lactide-co-glycolide)/N-methyl-2-pyrrolidone and deionized water as gel forming and release medium were prepared. Release profiles were constructed. Data revealed that the burst and prolongation of the release increases as well as drug loading increase
کلمات کلیدی: Sol-gel delivery system, Buprenorphine hydrochloride, PLGA, Drug loading
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/368496/