Synthesis and characterization of derived imines from 4-imino-5,6,7,8- tetrahydro-1-benzothieno[2,3-d]pyrimidin-3(4H)-amine
- سال انتشار: 1392
- محل انتشار: فصلنامه ارتباطات شیمی ایران، دوره: 2، شماره: 1
- کد COI اختصاصی: JR_ICC-2-1_002
- زبان مقاله: انگلیسی
- تعداد مشاهده: 578
نویسندگان
Department of Chemistry, Payame Noor University, P.O. BOX ۱۹۳۹۵-۴۶۹۷, Tehran, Iran
Department of Chemistry, Payame Noor University, P.O. BOX ۱۹۳۹۵-۴۶۹۷, Tehran, Iran
Department of Chemistry, Payame Noor University, P.O. BOX ۱۹۳۹۵-۴۶۹۷, Tehran, Iran
چکیده
The synthesis and characterization of derived imines from 4-imino-5,6,7,8-tetrahydro-1-benzo thieno[2,3-d]pyrimidin-3(4H)-amine 3 have been developed in three steps through the reaction of heteroaromatic o-aminonitrile 1 with triethyl orthoformate. The process afforded the corresponding of imido ester 2 and was followed by cyclization with hydrazine hydrate to furnish iminothienopyrimidineamine 3 and, finally, the imination of 3 with aromatic aldehydes generated the corresponding imines (5a-5h). It is worth mentioning that the process was done at room temperature. The new products were obtained in high yield with an easy work-up in simple reaction along with the purification of products by non-chromatographic method. This generalsynthetic procedure which can be extended to the preparation of wide variety of imines using o-aminonitrile bifunctional derivatives can also be synthesized by Gewald reaction.کلیدواژه ها
Thieno[2,3-d]pyrimidines, o-aminonitrile, imination, Gewald reactionمقالات مرتبط جدید
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