Immunofluorescence Pattern of Autoimmune Bullous Diseases in Iranian Patients

  • سال انتشار: 1391
  • محل انتشار: فصلنامه آسیب شناسی ایران، دوره: 7، شماره: 4
  • کد COI اختصاصی: JR_IJP-7-4_004
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 939
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نویسندگان

Alireza Monsef

Dept. of Pathology, School of Medicine, Hamedan University of Medical Sciences, Hamadan, Iran

Mahmood Farshchian

Dept. of Dermatology, School of Medicine, Hamedan University of Medical Sciences, Hamadan, Iran

Mohammad Jafari

Dept. of Pathology, School of Medicine, Hamedan University of Medical Sciences, Hamadan, Iran

Mehdi Farshchian

Dept. of Dermatology, School of Medicine, Hamedan University of Medical Sciences, Hamadan, Iran

چکیده

Background & Objective: Autoimmune bullous diseases are associated with autoimmunity against structural components in the skin and mucous membranes. Autoantibodies are againstthe intercellular junctions in pemphigus disease and hemidesmosomal unchoring complex in pemphigiod diseases and epidermolysis bullosa aquisita. The tissue-bound and circulating serum autoantibodies can be detected with direct immunofluorescence (DIF) and indirectImmunofluorescence (IIF) tests. The aim of this study was to pinpoint the immunofluorescence pattern of Iranian patients with autoimmune bullous diseases. Methods: In a prospective case series study, sixteen patients with autoimmune disease enrolled inthe study for two years. Perilesional skins and sera from the patients were used in DIF and IIF for detection of immunofluorescence pattern.Results: Out of 16 cases, 9 cases had pemphigus and 7 cases had bullous pemphigoid. All cases of pemphigus had positive DIF in intercellular region with lacelike pattern; IgG was detected in all cases, IgA in 1(11.1%) case and C3 in 3 (33.3%) cases. One (11.1%) case of pemphigus had positiveIIF in intercellular region with lacelike pattern; circulating autoantibodies were IgG and IgA. All cases of bullous pemphigiod had positive DIF in dermal-epidermal Junction with linear pattern.IgG was detected in all cases, IgM in one (14.3%) case, and C3 in six (85.7%) cases. One (14.3%)case of bullous pemphoid had positive IIF in dermal-epidermal Junction with linear pattern; circulating autoantibody was IgG.Conclusion: Immunofluorescence tests are sensitive diagnostic methods for autoimmune bullous diseases. IIF positive cases in our study were lower compared to the previous reports.

کلیدواژه ها

Immunofluorescence, Bullous Skin Diseases, Iran

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