Lipid Profile in Subjects with Helicobacter pylori Infection
محل انتشار: فصلنامه آسیب شناسی ایران، دوره: 5، شماره: 4
سال انتشار: 1389
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 614
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شناسه ملی سند علمی:
JR_IJP-5-4_005
تاریخ نمایه سازی: 5 آبان 1393
چکیده مقاله:
Background and Objectives: Helicobacter pylori cause a chronic gastric infection, and may cause extra gastrointestinal disease. The association between H. pylori infection and serum lipid profilesis still controversial. The aim of this study was to investigate any possible relationship between H.pylori infection and lipid levels. Materials and Methods: The subjects were 400 volunteer referring to medical centers of Kashan, Iran between December 2005 and March 2006. Helicobacter pylori infection status was determined by assaying serum anti-H. pylori immunoglobulin G antibody. Total cholesterol, HDL-cholesterol,triglyceride concentrations were measured by routine enzymatic methods. The data for H. pyloriseropositiveand –seronegative individuals were compared. Results: Three hundred nineteen subjects (79.8 percent) were H. pylori-seropositive. The serumtriglyceride concentration and total cholesterol/HDL-cholesterol ratio were significantly higher in H. pylori-seropositive than H. pylori–seronegative individuals (162.03 vs. 143.88 mg/dl, P<0.05 and 4.27 versus 3.91, P<0.05 respectively). Conclusion: The findings confirm the existence of a moderate association between H. pylori infection and lipid modulation. It is also possible that H. pylori infection promotes atherosclerosis by acting through changes in lipid profile.
کلیدواژه ها:
نویسندگان
Mohamad Hosein Aarabi
Dept. of Clinical Biochemistry, Kashan University of Medical Sciences, Kashan, Iran
Shokofeh Alvani
Dept. of Physiology and Pharmacology, Kashan University of Medical Sciences, Kashan, Iran
Hassan Ehteram
Dept. of Pathology, Kashan University of Medical Sciences, Kashan , Iran