Behavioral and Histological Analysis of Crocus Sativus Effect in Intracerebroventricular Streptozotocin Model of Alzheimer Disease in Rats

سال انتشار: 1389
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 769

فایل این مقاله در 7 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

JR_IJP-5-1_005

تاریخ نمایه سازی: 5 آبان 1393

چکیده مقاله:

Background and Objectives: There is well established the beneficial effects of Crocus sativus extract in learning and memory improvement. In the present study the effect of this plant in memorybehavioral impairment and forbrain histological damage induced by STZ-icv model of Alzheimer disease were investigated. Materials and Methods: This study was conducted at Shahed University (Tehran) in 2007. Forty five male rats were divided into three 15 number groups: 1- Control which received CSF bilaterally two times in 1 and 3 days (10 μl in each injection ) 2- STZ-icv, streptozotocin (3 mg/kg) dissolvedin CSF was injected (icv) to the animals. 3- STZ+CSE, the STZ-icv animals received the plant extract (30 mg/kg; i.p) one other day as treatment ones. All of the animal groups were weighted and subjected to memory behavioral passive avoidance test and brain histological damage analysis.Results: STZ caused selective injury to the fornix and hippocampus and an enlargement as well as loss of ependymal cell in third ventricle. However, STZ-icv treated animals with CSE (30 mg/kg, i.p) one other day starting one day pre-surgery for three weeks show higher correct choice andlower errors in shuttle box test than vehicle-treated STZ-injected rats. But the same CSE treatment rats did not show any antagonizing effects on STZ-icv induced histological impairment. Conclusion: Our findings provide an explanation for effectiveness of CSE in preventing thecognitive deficits caused by STZ-icv in rats, which mediated by enzymes, metabolisms (glucose utilization) and other biochemical pathways, but not via histological injury repair.

نویسندگان

Mohsen Khalili

Dept of Physiology and Neuroscience Research Center, Shahed University of Medical Science, Tehran, Iran

Zahra Kiasalari

Dept of Physiology and Neuroscience Research Center, Shahed University of Medical Science, Tehran, Iran

Batol Rahmati

Dept of Physiology and Neuroscience Research Center, Shahed University of Medical Science, Tehran, Iran

Jamshid Narenjkar

Dept of Pharmacology, Shahed University of Medical Science, Tehran, Iran