Correlation between Soluble Vascular Endothelial Growth Factor A and its Receptor 1 with Response to Chemotherapy in Acute Leukemia in Children

سال انتشار: 1387
محل انتشار: فصلنامه آسیب شناسی ایران، دوره: 3، شماره: 4
کد COI اختصاصی: JR_IJP-3-4_001
زبان مقاله: انگلیسی
تعداد مشاهده: 818

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نویسندگان

Mitra Mehrazma

Dept. of Pathology, Ali-Asghar Hospital, Iran University of Medical Sciences, Tehran, Iran.

Khadijeh Arjomandi Rafsanjani

Dept. of Pediatric Hematology and Oncology, Iran University of Medical Sciences, Tehran, Iran.

Behzad Torkamanipoor

Iran University of Medical Sciences, Tehran, Iran

چکیده

Background and Objective: Vascular endothelial growth factor (VEGF) and its receptors (VEGF-R1 and R2) are major regulators of angiogenesis. This study was designed to assess serumlevels of VEGF and VEGF-R1 and their prognostic significance in newly diagnosed childhood acute leukemia. Materials and Methods: For this purpose, VEGF and VEGF-R1 were determined using enzyme linked immuno-sorbant assay (ELISA) in samples obtained before treatment. Demographic datawere recorded. Bone marrow blast percentage was counted on diagnosis and 2 weeks after inductiontherapy. A p value less than 0.05 considered significant. Results: Fifty-three children (22 boys and 31 girls) with newly diagnosed acute leukemia wereenrolled in the study. Most cases (56.6%) were pre B cell ALL. Mean value of VEFG-A in good responders was 55.13 ± 24.96 pg/ml and in poor responders it was 94.46 ± 15.75 (p< 0.0001). Meanvalve of VEGF-R1 in good and poor responders was 0.132 ± 0.0653 and 0.1665 ± 0.0857 pg/mlrespectively (p> 0.05). Using ROC curve, we found out a cut-off point of 76 pg/ml to discriminate poor response to chemotherapy.Conclusion: Soluble VEGF-A is an independent factor for response to therapy in childhood leukemia and leukemic patients with sVEGF-A level over 76 pg/ml will have poor response to treatment.

کلیدواژه ها

Vascular Endothelial Growth Factor Receptor-1, Leukemia, Child,Vascular Endothelial Growth Factor A

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