Mohssen Nassiri Toosi - Dept. of Internal Medicine, Tehran University of Medical Sciences, Tehran, Iran
Manije Lak - Iranian Hemophilia Center, Tehran, Iran.
Katayoun Karimi - Iranian Hemophilia Center, Tehran, Iran
Mohammadreza Managhchi - Iranian Hemophilia Center, Tehran, Iran

Background and Objective: Although transfusion therapy has lead to great improvement in longevity for hemophiliacs, but there have been tragic setbacks especially from transmission ofhuman immunodeficiency virus (HIV) and hepatitis C virus (HCV), HIV was reported to increase the rate of HCV-related liver failure by 4.2 times. In this study, we aimed to determine the seroprevalence of HIV and HCV, the association of HCV with abnormal liver tests, impact of HIVon HCV-related abnormalities and the distribution of HCV genotypes in Iranian hemophiliacs. Patients and Methods: In a cross-sectional study, we determined virological, clinical and epidemiological characteristics for HIV and HCV infection of 236 hemophiliacs attending ourcenter. Data were analyzed using Chi-square test. Results: Ten (4.7%) out of 211 patients tested were HIV seropositive and 145 (83.3%) were HCVseropositive. All tested positive HIV patients also had HCV. HCV seroprevalence was significantly higher in patients with hemophilia A and B as compared to other congenital coagulopathies and itwas directly related to coagulation severity. HCV seroprevalence was lower in hemophiliacs withpositive HBsAg (p = 0.03) but it did not differ by HBcAb or HBsAb results. HCV genotype 1a (48.5%) was predominant type and genotype 3a (33.3%) was also common. Frequency of abnormalaspartate aminotransferase and alanine aminotransferase liver enzymes was significantly higher inthe HCV positive group (p = 0.006). Conclusion: This study provides evidence that hepatitis c virus infection is a major problem forIranian hemophiliacs and it has higher prevalence in hemophiliacs with higher age, more severe coagulopathies, abnormal alanine aminotransferase level, and human immunodeficiency virus coinfection.

Hepatitis C, Hemophilia, Human Immunodificiency Virus