Estrogen Accelerates Wound Angiogenesis in Rats

  • سال انتشار: 1387
  • محل انتشار: فصلنامه آسیب شناسی ایران، دوره: 3، شماره: 1
  • کد COI اختصاصی: JR_IJP-3-1_002
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 875
دانلود فایل این مقاله

نویسندگان

Mohammad Ali Rajabi

Dept. of General Surgery, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

Fatemeh Rajabi

Education Development Office (EDO), School of Medicine, Isfahan University of Medical Sciences,Isfahan, Iran

Parvin Rajabi Dehnavi

Dept. of Pathology, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

Mitra Heidarpour

Dept. of Pathology, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.

چکیده

Background and Objective: Angiogenesis is a complex program of several steps and it is tightly regulated by pro- and anti-angiogenic factors. Angiogenesis is one of the key elements in cutaneouswound healing and skin cancers. Estrogen seems to have positive modulating effect on cutaneouswound healing and this effect may be explained by its angiogenic properties. This study aims to investigate the effect of estrogen on cutaneous wound angiogenesis in rats through histologicalcriteria. Materials and Methods: This was an experimental study which was carried out at EsfahanUniversity of Medical Sciences in August 2007. Forty rats were randomly allocated into two groups and an experimental wound was induced in their skin. Wounds in the case group were treated withdaily topical estrogen and gentamicin, while the controls received only topical gentamicin. After 14days of treatment, biopsies were obtained. Results: Evaluation of wounds through a validated histological scoring system revealed significantdifference between control and treated mice. The latter exhibited increased microvasculature and significantly higher scores of angiogenesis. Conclusion: Our study suggests that topical estrogen is able to increase cutaneous wound angiogenesis considering objective histological criteria.

کلیدواژه ها

Angiogenesis Inducing Agents, Wound healing, Estrogen

مقالات مرتبط جدید

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.