Risk Factors and Seroprevalence of Hepatitis B and C Infections among Hemodialysis Patients in Tehran

  • سال انتشار: 1386
  • محل انتشار: فصلنامه آسیب شناسی ایران، دوره: 2، شماره: 4
  • کد COI اختصاصی: JR_IJP-2-4_007
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 714
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نویسندگان

Mohssen Nassiri Toosi

Dept. of Gastroenterology and Hepatology, Tehran University of Medical Sciences, Tehran, Iran

Farzaneh Larti

Dept. of Gastroenterology and Hepatology, Tehran University of Medical Sciences, Tehran, Iran

Mehrnaz Rasteh

Dept. of Gastroenterology and Hepatology, Tehran University of Medical Sciences, Tehran, Iran

Hosein Foroutan

Dept. of Gastroenterology and Hepatology, Tehran University of Medical Sciences, Tehran, Iran

چکیده

Background and Objective: Viral hepatitis is the most frequent disease as a complication of hemodialysis treatment. Because of the importance of reducing the risk of infection, we decided tostudy the seroprevalence and possible predisposing factors of hepatitis B and C infections.Materials and Methods: The prevalence of hepatitis B and C serologic markers and risk factors were assessed in 130 hemodialysis patients in two university-affiliated hospitals in Tehran. Samplepopulation included 52 women and 78 men with the mean age of 52.9 years and the mean durationof hemodialysis of 4.83 years. Results: The seroprevalence of antibodies against the hepatitis C virus (anti-HCV) and hepatitis B surface antigen (HBsAg) were 8.5% and 4.6%. Out of all patients, 55.4% and of vaccinated individuals, 71.3% had positive hepatitis B surface antigen antibody (HBsAb). There was also asignificant correlation between anti-HCV positivity and the mean duration of hemodialysis (p=0.00). However, there was no relationship found between the history of transfusion and anti-HCV orHBsAg positivity (p = 0.98, p = 0.71). Among aminotransferases, aspartate transaminase (AST)level had only a relationship with positive HBsAg (p = 0.02). Conclusion: Correlation of duration of hemodialysis with the presence of antibodies against HCV strongly supports that the hemodialysis environment is as a source of transmission of this disease. High prevalence rate of HBsAg positivity in the hemodialysis units needs more restricted rules for immunization with HBV before beginning the hemodialysis program.

کلیدواژه ها

Hepatitis B, Hepatitis C, Hemodialysis

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