Metabolic Abnormalities in HIV-Positive Patients Receiving Highly Active Antiretroviral Therapy

  • سال انتشار: 1386
  • محل انتشار: فصلنامه آسیب شناسی ایران، دوره: 2، شماره: 4
  • کد COI اختصاصی: JR_IJP-2-4_003
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 721
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نویسندگان

Amitis Ramezani

Dept. of Clinical Research, Pasteur Institute of Iran, Tehran, Iran

Minoo Mohraz

Iranian Research Center for HIV/AIDS, Tehran, Iran

Mohammad Banifazl

Iranian Society for Support of Patients with Infectious Disease, Tehran, Iran

Latif Gachkar

Infectious Diseases Research Center, Shaheed Beheshti Univ. Med. Sci., Tehran, Iran

چکیده

Background and Objective: Dyslipidemia has become a common problem in human immunodeficiency virus (HIV) disease, especially in patients on combination antiretroviral therapy.In this study we aimed to determine the prevalence of dyslipidemia and metabolic abnormalities in 2 groups of HIV infected patients receiving highly active antiretroviral therapy (HAART) and antiretroviral-naive patients. Patients and Methods: Forty HIV infected patients treated by HAART as a case group (6 femalesand 34 males) with a mean age of 40.7 ± 10 years and 15 HIV naïve as a control group (2 females and13 males) with a mean age of 38.40 ± 8.3 enrolled in this study. The two groups were well matched in respect to age, sex and CD4 cell counts. A standardized questionnaire with epidemiological, clinical,and therapeutic data was completed by physicians. Blood samples were obtained for metabolicmeasurements. CD4 positive cell count was measured by f lowcytometry. Results: Levels of total cholesterol, triglycerides, LDL, HDL, lactate, and FBS were elevated in24%, 37%, 3.7%, 44.4%, 29.6% and 11% of patients respectively. There was a significant differenceregarding mean total cholesterol and LDL between treated group and controls (p< 0.05). There was also no significant difference between treated group and controls regarding triglyceride, HDL,lactate and FBS levels. Conclusion: Our study demonstrated that metabolic abnormalities are relatively common inHIV-infected patients receiving HAART. Therefore, it is recommended to screen the HIV infectedpatients on HAART for metabolic disorders, potential of morbidity, and possible long-term cardiovascular risk factors.

کلیدواژه ها

Dyslipidemia, Hyperglycemia, HIV, Highly active antiretroviral therapy

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