The Role of Interleukin 1β Gene Polymorphism in Gastric Cancer in North-eastern Iran

  • سال انتشار: 1386
  • محل انتشار: فصلنامه آسیب شناسی ایران، دوره: 2، شماره: 2
  • کد COI اختصاصی: JR_IJP-2-2_003
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 802
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نویسندگان

Mehdi Seilanian Toosi

Ward of Radiotherapy Oncology and Cancer Research Center, Omid Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

Jalil Tavakkol Afshar

Dept. of Immunology and Bu-Ali Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Mohamad Reza Ghavam Nassiri

Ward of Radiotherapy Oncology and Cancer Research Center, Omid Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

Mona Malekzadeh Moghani

Ward of Radiotherapy Oncology and Cancer Research Center, Omid Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

چکیده

Background and Objective: Host genetic factors such as cytokine gene polymorphisms as well as Helicobacter pylori (H. pylori) infection have been found to be associated with gastric cancer risk.Interleukin 1 is a pro-inflammatory cytokine involved in H. pylori-induced gastric inflammation.Therefore, we analyzed the association between IL-1β and IL-1-RN polymorphisms and gastric cancerin Persian residents in north-eastern Iran.Methods: In a case-control study, the genotyping was carried out by PCR-RFLP in 109 gastric cancerpatients and 101 randomly-selected healthy controls. The polymorphic sites include promoter region of IL-1β at 511 (C-T transition) position and IL-RN VNTR H. pylori infection was determined by ELISAassay in patients. Results: No significant differences were observed in the allele and genotype frequency of IL-1β-511 and IL-1RN VNTR between patients and control. Genotype frequencies in healthy controls were notsignificantly different from gastric cancer cases in separate histological types (intestinal or diffuse). IL-1β-511 CT genotype frequency was significantly higher among healthy subjects than H. pylori positivegastric cancer patients (41.6% vs. 20%, p = 0.01, OR 0.30, 95% CI: 0.11-0.76). Meanwhile, relativelyhigher frequency of IL-1β-511 T genotype was observed among H. pylori positive cases as compared tohealthy controls (42.9% vs. 26.7%, p = 0.06, OR 2.16, 95% CI: 0.96-4.8) Conclusion: Our results suggest the association between IL-1β-511 polymorphism and H. pylori infection and their contribution to the risk of gastric cancer. While IL-1β-511 CT genotype has a protective effect against H. pylori associated gastric carcinoma, IL-1β-511 TT may increase the risk.

کلیدواژه ها

Gastric cancer, Genetic polymorphism, Interleukin 1, Receptor, Antagonist, Helicobacter pylori

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