Serum and Urine Level of Zinc in Patients with Minor Beta Thalassemic in Ali-asghar Hospital During the Years 2005-2006

سال انتشار: 1386
محل انتشار: فصلنامه آسیب شناسی ایران، دوره: 2، شماره: 2
کد COI اختصاصی: JR_IJP-2-2_002
زبان مقاله: انگلیسی
تعداد مشاهده: 759

نویسندگان

Dept. of Pathology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran

Dept. of Infectious Diseases and Pediatrics, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Massih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences,Tehran, Iran

چکیده

Introduction and Objective: Zinc as the second trace element of the human body plays an important role in numerous functions. A large number of research studies have showed serum zinc deficiency andexcess urinary excretion in patients with major beta thalassemia, but few studies revealed excess urinary zincexcretion in minor beta thalassemia and no study investigated serum zinc levels in this group. This study aimed to measure serum and urine zinc level in patients with minor beta thalassemia. Materials and Methods: The study was observational and cross-sectional. Blood and 24-hour urinesamples were collected from carriers of beta thalassemia who attended Ali Asghar Hospital for blood transfusions for their children. They had documented hemoglobin electrophoresis for their status. The serum and urine zinc levels were measured by atomic absorption spectrophotometer. Student’s t test was used forcomparison of groups. Results: The average level of zinc in the serum and urine of the male cases was 69 ± 10 μg/dl and 714 ±162 μg/dl and in the female cases was 58 ± 11 μg/dl and 751 ± 162 μg/dl respectively and was 64 ± 12 μg/dland 730 ± 120 μg/dl totally. The obtained serum zinc was lower and the urine zinc was higher in minor beta thalassemic persons than the amounts mentioned by references for the subjects of the same sex and age. Theserum zinc level of anemic patients with minor beta thalassemia was lower (63 ± 11 vs 72 ± 13 μg/dl) andthe urine zinc level was higher (792 ± 183 vs 673 ± 202 μg/dl) than non-anemic patients. Conclusion: Minor beta thalassemics have lower serum zinc level and due to abundant roles of zinc can make benefit from zinc supplementation. This decrement may be attributed to tubulopathy in these patients

کلیدواژه ها

Minor thalassemia, Zinc, Urine, Serum

مقالات مرتبط جدید

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.