Radiation-induced Hypothyroidism in Head and Neck Malignancy

سال انتشار: 1386
محل انتشار: فصلنامه آسیب شناسی ایران، دوره: 2، شماره: 2
کد COI اختصاصی: JR_IJP-2-2_001
زبان مقاله: انگلیسی
تعداد مشاهده: 685

نویسندگان

Dept. of Oncology, Arak University of Medical Sciences, Arak, Iran

Hamedan University of Medical Sciences, Hamedan, Iran

چکیده

Background and Objective: Hypothyroidism is a known consequence of the external beam radiotherapy to the neck encompassing the thyroid gland for over 40 years. The aim of this studywas to find out the incidence of hypothyroidism in patients with head and neck cancer treated withradiotherapy, when radiation portals included whole of the thyroid gland.Materials and Methods: This prospective non-randomized study was conducted from December2004 to February 2006. In this regard, 39 patients with head and neck malignancies referred to radiation oncology center of Hamedan whom treated with the external beam radiotherapy, whoseradiation portals included the whole of the thyroid gland. Thyroid function tests were done at thebeginning of treatment, one month, three months, six months, and one year after the completion of radiotherapy.Results: Out of 39 patients, two were excluded from the study as they had history of hypothyroidbefore the initiation of treatment. The next two were excluded from data analysis because they didnot undergo regular follow-up. Of the patients attending the follow-up clinic, 31% were found tohave sub-clinical hypothyroidism (TSH> 4.5 mU/l) during a year. Conclusion: Since a significant number of patients developed hypothyroidism followingradiotherapy on the neck, thyroid function tests should be included in the routine follow-up protocol of such patients. Certain questions have emerged from this study, which need a large randomized study to find out the answers.

کلیدواژه ها

Hypothyroidism, Thyroid function tests, Cancer of Head and neck

مقالات مرتبط جدید

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.