Chromosomal Analysis Of Couples With Bad Obstetric Histoty

Background and Objective: Pregnancy termination and recurrent abortion are one of the common complications during pregnancy and in patients with a bad obstetric history.Materials and Methods: In this study, a total of 154 individuals including 75 couples and four single women from different communities and with various incomes were investigated forchromosomal abnormalities using blood culture and chromosomal banding technique.Results: Chromosomal analysis of these patients revealed three abnormal karyotypes (3.8%) in three women and two abnormal karyotypes in conceptions. Two of these couples hadconsanguineous marriage and the remaining women included one isochromosome for X [46, x,I(xq)], two translocations [45, xx, t (15:21)] and [46, xx, t (7:14)], one trisomy ‘21’ (47, xx, +21), and a ring chromosome (46, xx, r(X). In addition, 27 conceptions had been reported for these five couples.These included 23 abortions with 18 of them within first trimester (78.26%) and four of them hadabortions within second trimester (21.74%), one had a normal child, three had abnormal children, and one with stillbirth. Conclusion: It was found out that abnormal karyotype is present in 3.8% of patients with a badobstetric history. There was also a close relationship between number of deliveries and abortions and this relation was statistically significant (p<0.01). In addition, consanguinity was also relatedwith number of abnormal children (p<0.05). There was also a significant relationship between consanguinity and first trimester abortions (p<0.05). Therefore, in couples with more than threeabortions, especially within first trimester, chromosomal evaluation can have a diagnostic value.

کلیدواژه ها:

Obstetric history ، Karyotype ، Chromosomal abmormalities ، Abortion