Histopathological changes of the antigen-induced chronic arthritis in the knee joint of the rabbit

سال انتشار: 1385
محل انتشار: فصلنامه آسیب شناسی ایران، دوره: 1، شماره: 2
کد COI اختصاصی: JR_IJP-1-2_001
زبان مقاله: انگلیسی
تعداد مشاهده: 1074

نویسندگان

Department of Pathology, Afzalipour Medical School,Kerman University of Medical Sciences, Kerman

Physiology Research Center and Department of Physiology, Afzalipour Medical School,Kerman University of Medical Sciences, Kerman

Saeed Niazmand

Physiology Research Center and Department of Physiology, Afzalipour Medical School,Kerman University of Medical Sciences, Kerman

Hamid Tabrizchi

Department of Pathology, Afzalipour Medical School,Kerman University of Medical Sciences, Kerman

چکیده

Background and Objectives: The cause and pathophysiology of rheumatoid arthritis has not been fully understood and an experimental model of this disease is essential for research on theproblem. In this research study, establishment and histopathological changes of chronic arthritis due to intra-articular antigen injection was used as a model of experimental rheumatoid arthritis. Materials and Methods: Thirty three New-Zeeland white rabbits were sensitized bysubcutaneous injection of combination of methylated bovine serum albumin (MBSA) and Freund’s complete adjuvant (FCA) at days 1 and 14. Sensitized animals at day 28 received intra-articular injections of MBSA. At days 7, 14, 21, and 28 post-injection, excised knee joints were investigatedfor routine light microscopic changes.Results: It was found out that at day 7 there are fibrinous exudates in the joint space andpericapsular soft tissue, edematous synovial villi, and an intact cartilaginous site of joint. At day 14, lymphoid follicle formation at pericapsular area, short and widening of synovial villi, superficialerosion of joint cartilage (perichondritis) was observed. Thereafter, at day 21 increased secondarylymphoid follicles with active germinal centers at pericapsular areas, papillary hyperplasia of the synovial villi, thinning of the cartilaginous site of joint with mononuclear cellular infiltrates (chondritis) was noted. In addition, day 28 was demarcated by continuation of the chondritis andbeginning of osteitis, granulation tissue formation (Pannus) at cartilaginous site of joint, and fibrotic changes of the synovial villi. Rare findings including pseudocyst space and palisading granuloma at the pericapsular area was also observed. Conclusion: Antigen-induced chronic arthritis in the knee joint of the rabbit is a good experimental model to evaluate the pathogenesis and/or effects of drug interferences in the rheumatoid arthritis.

کلیدواژه ها

Chronic inflammation, Rabbit, Immune-arthritis, Histopathology,Rheumatoid arthritis

مقالات مرتبط جدید

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.