Relationship between grade and MDM2 oncoprotein overexpression in transitional cell carcinoma of the urinary bladder

  • سال انتشار: 1384
  • محل انتشار: فصلنامه آسیب شناسی ایران، دوره: 1، شماره: 1
  • کد COI اختصاصی: JR_IJP-1-1_004
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 752
دانلود فایل این مقاله

نویسندگان

Mohammad Reza Jalali Nadoushan

Dept. Pathology, School of Medicine, Shahed University, Tehran

Ehsanollah Ghorbanian

School of Medicine, Shahed University, Tehran

Touraj Taheri

Pathologist

چکیده

Objective: Transitional cell carcinoma (TCC) of the urinary bladder is the second common cancer of the genitourinary tract. Several parameters such as clinical and pathologicalparameters, molecular factors, and etc play a role in determination of prognosis and type of treatment. In this research study, the relationship between grade and MDM2 oncoproteinoverexpression in TCC of bladder was evaluated. Material and Methods: This cross-sectional study was carried out on 75 paraffinembedded tissue blocks (deposited in Pathology Department) from patients with TCC ofurinary bladder from 2002 to 2005. In this respect, 3 μm sections were taken from eachblock. In one of the sections, grade of tumor was determined according to WHO/ISUPcriteria using hematoxylin-eosin staining method. In another section, percent of MDM2 positive cells were determined by microscopic observation of 100 cells in each section usingimmunohistochemical technique and specific antibody. Results: Mean of MDM2 positive cells was %9.08 ± 4.7. In addition, mean of MDM2 positive cells in low malignant potential tissue (grade I), low grade tissue (grade II), andhigh grade tissue (grade III) was %3.6 ± 2.2, %8.2 ±3.5, and %13.1 ± 3.4 respectively. Meanwhile, a significant relationship was found out between grade and overexpression ofMDM2 oncoprotein (p = 0.012). Conclusion: Overexpression of MDM2 oncoprotein exhibits a direct relationship withgrade of TCC of the urinary bladder. The obtained results were consistent with the most previous studies. Therefore, through performing studies with a greater follow-up and entailing a larger population of patients, overexpression of MDM2 oncoprotein could be used as a prognostic parameter in TCC of urinary bladder.

کلیدواژه ها

Transitional Cell Carcinoma of the urinary bladder (TCC),Grade, MDM2 oncoprotein

مقالات مرتبط جدید

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.