Trophoblast stem cells equipped with HLA-G: Key to immune tolerance in pregnancy or Invasion without Protection
- سال انتشار: 1391
- محل انتشار: نخستین همایش ملی تازه های سلولی مولکولی
- کد COI اختصاصی: NCNCMB01_167
- زبان مقاله: انگلیسی
- تعداد مشاهده: 897
نویسندگان
Basic Science Department, Shiraz University, Shiraz, Iran
Basic Science Department, Shiraz University, Shiraz, Iran
Basic Science Department, Shiraz University, Shiraz, Iran
چکیده
background Multiple mechanisms underlie the surprising willingness of mothers to tolerate genetically different fetal tissues during pregnancy. Chief among these is the choice of HLA-G, a gene, for expression by the placental Trophoblast cells that interface directly with maternal blood and tissues. In this article, we first briefly discuss a number of conditions responsible for immune privilege and maternal tolerance for which scientific evidence is strong, then focus on a central feature-a unique capacity and function of placental Trophoblast cell .cells for HLA-G expression and secretion Method For this review, computerized literature searches of Medline was carried out to identify the trend of scientific production of original researches in the field results.2012 and 1991 of maternal tolerance during about two decades, between HLA-G,was first identified in placental trophoblast cells, the unique lineage of cells derived from the trophectoderm layer of the blastocyst that interfaces directly with maternal uterine and blood cells. In particular, it has been learned that although membrane isoforms are present on invading cytotrophoblast cells, soluble isoform is synthesized in placental villous cytotrophoblast HLA-G5 (vCTB) cells. Recent studies indicate that suppression may be promoted by binding of soluble or membrane-bound HLA-G produced in placentas to and LILRB2 )ILT2( inhibitory receptors on leucocytes known as LILRB1 +Immune cells driven into suppressive modes by HLA-G include CD8 .)ILT4( +lymphocytes, natural killer (NK) cells, activated macrophages and CD4 cells. Furthermore, Some studies demonstrated that HLA-G in +CD25 cytotrophoblasts, may act as a key role in both genetic susceptibility to, and pathogenesis of pre-eclampsia(PE), but this pathway is obscure until now. So, We propose and illustrate this hypothesis for the first time that HLA-G in cytotrophoblasts provide CTB invasion in to deciduas tissues .without any maternal immune responses or protection Conclusion Additional studies are warranted to develop a more complete understanding of the mechanisms involved in the interaction between the HLA-G that placental Trophoblast cell express and fetomaternal tolerance. HLA-G expression, which appears to be a key component in trophoblast invasion and responsible in large part for the reprogramming of maternal immune responses into suppressive modes that characterize .successful semiallogeneic pregnancyکلیدواژه ها
Trophoblast cells; HLA-G; Maternal tolerance; Pregnancyمقالات مرتبط جدید
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