Fatemeh Beheshti - Quchan Branch,Islamic Azad University-Quchan, Iran
Z Bayat - Department of Chemistry,Quchan Branch,Islamic Azad University-Quchan, Iran
H Sadeghian - Pharmaceutics School of Pharmacy, University of Medical Sciences(MUMS), Mashhad, Iran

There are over 200 different known cancers that afflict humans.The causes of cancer are diverse, complex, and onlypartially understood. Many things are known to increase the risk of cancer, including tobacco use, dietary factors, certaininfections, exposure to radiation, lack of physical activity, obesity, and environmental pollutants Gold nanoparticles(AuNPs) provide non-toxic carriers for drug and gene delivery applications. An additional attractive feature of AuNPs is theirinteraction with thiols, providing an effective and selective means of controlled intracellular release. selective targeting offolate-receptor positive cancerous cells. The linker chosen were 4-aminothiophenol (4Atp) with nanoconjugate products namedFolate-MH-AuNP. We report the folate-receptor tissue. This demonstrates that folate targeting is effective in selecting forspecific cell populations. We also know that folate receptor (FR) is a confirmed tumor-associated antigen that binds folateand folate–drug conjugates with very high affinity and shuttles these bound molecules inside cells via an endocytic mechanism.Now we have a folate connecting by the linker 6-mercapto-1- hexzanol to two Gold nanoparticles (AuNP). In this report, theMolecular Structure, and some Geometrical properties (Bond lengths and Bond angles) folate-6mercapto-1-hexzanol-AuNPwere investigated using the Density Functional Theory (DFT) calculations[1.2.3].

DFT calculations, cancer, 4-aminothiophenol , folate, folate receptor, folic acid , Gold nanoparticle