Studying Genes And Biological Pathways In Pancreatic Cancer

Pancreatic cancer remains one of the most lethal malignancies, characterized by a high mortality rate and a rising global incidence. Pancreatic tumors are classified as immunologically 'cold' due to their suppressive phenotype, which inhibits immune system activation and renders them resistant to conventional therapies, including immunotherapy. In this study, gene expression profiling was conducted using data retrieved from the NCBI Gene Expression Omnibus (GEO) database. Specifically, dataset GSE۲۳۵۵۱۶, processed with platform GPL۲۴۶۷۶, was utilized. This platform represents a multi-array intermediate designed for RNA-based robust backend transformation using ۲LogFC normalization. Quality control of the array was performed using R-based statistical fields. Subsequent analyses focused on pancreatic cancer-specific gene expression patterns and signaling pathways. Differentially expressed genes and enriched pathways were identified, many of which showed upregulated expression consistent with findings from previous studies. According to the studies conducted, it is observed that there is a significant increase in tumor tissue compared to the tumor margin, considering ۵>LogFC>-۵ and P-value <۰.۰۵.

کلیدواژه ها:

Pancreatic cancer ، Gene ، Long non-coding RNA (LncRNA) ، Metastasis