Effectiveness and Safety of Second-Generation Antipsychotics for Psychiatric Disorders Apart from Schizophrenia: A Systematic Review and Meta-Analysis

  • سال انتشار: 1404
  • محل انتشار: Medicinal, Psychological, and Health Research Journal، دوره: 1، شماره: 10
  • کد COI اختصاصی: JR_MPHRJ-1-10_001
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 86
دانلود فایل این مقاله

نویسندگان

Parisa Hamidi

Assistant Professor of Psychiatry, Department of Psychiatry, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

چکیده

Introduction: Understanding the effectiveness and safety of second-generation antipsychotics in psychiatric disorders beyond schizophrenia is crucial, given their expanding off-label use and distinctive side effect profiles. Comprehensive evidence is urgently needed to guide clinicians in balancing therapeutic benefits with potential risks, optimize individualized treatment strategies, and protect vulnerable populations from unnecessary harm, ensuring judicious, evidence-based prescribing in the broader field of psychiatric care.Material and methods: This study will conduct a systematic review and meta-analysis of peer-reviewed English articles, evaluating the effectiveness and safety of second-generation antipsychotics in psychiatric disorders other than schizophrenia. Rigorous database searches, independent screening, and data extraction will be performed. Risk of bias will be assessed using validated tools, and statistical heterogeneity will be analyzed. Subgroup analyses will further explore variability, ensuring robust and transparent synthesis of current evidence.Results: A comprehensive literature search across five major databases resulted in ۴۸۶.۳۴ records, with ۳۳۳.۶۷ unique studies screened after deduplication. Of these, ۲۸.۲۱ full-text articles were assessed for eligibility, leading to the inclusion of ۹.۰۳ high-quality studies. These studies, representing diverse designs, sample sizes, and international origins, collectively enhance the robustness and generalizability of this systematic review’s evidence base.Conclusion: Based on a rigorous screening of ۴۸۶.۳۴ records from multiple databases, only nine high-quality studies met the strict inclusion criteria, demonstrating substantial methodological robustness and international representation.

کلیدواژه ها

Second-Generation Antipsychotics, Psychiatric disorders, Systematic review, Safety and Efficacy

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.