Mathematical analysis of basic transmission dynamics model for Zika virus infection

In this article, we develop, validate and analyze an age-structured mathematical model of the Zika virus infection by incorporating vectorial, vertical and sexual transmission into the dynamics. The model is shown to be mathematically well-posed and epidemiologically feasible. Analysis of the model shows that, vectorial transmission contributes higher percent followed by sexual transmission, while vertical transmission in aquatic vectors contributes nearly insignificant percentage. Sensitivity analysis revealed that, the mosquito-human ratio constant, biting rate and the effective sexual contact rate are the most sensitive parameters in the disease reproduction numbers of the model.

کلیدواژه ها:

Zika virus ، age-structured model ، sexual transmission ، vertical transmission ، Model fitting ، Sensitivity analysis