Investigating the effect of tamoxifen on sperm viability in patients with oligospermia

  • سال انتشار: 1404
  • محل انتشار: بیستمین کنفرانس بین المللی بهداشت، درمان و ارتقای سلامت
  • کد COI اختصاصی: HWCONF20_044
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 50
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نویسندگان

Maryam Mohammadi

Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Hanieh Jahi

Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Shaghayegh Dehghan Kamanaj

Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tabriz, Tabriz, Iran

Shahla Eshaghi

Laboratory Technician, Shahid Beheshti Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

Kosar Alizadeh

Master of Science in Midwifery, Iran University of Medical Science, Tehran, Iran

Rabee Movagharnia

Department of Genetics and Biotechnology, School of Biological Sciences, Varamin-Pishva Branch, Islamic Azad University, Varamin, Iran

چکیده

Sperm quality analysis is the most basic and common test used in the field of fertility prediction, which is based on the estimation of important indicators such as motility, morphology and viability. Tamoxifen has been used in the treatment of male infertility, especially in cases of oligospermia and infertility of unknown origin. The aim of this study was to evaluate the effect of adding tamoxifen on sperm viability parameters in men with oligospermia. Semen was collected from ۲۰ oligospermic men aged ۳۰ to ۵۰ years, referring to infertility clinics, after ۳ to ۴ days of abstinence from intercourse and with full consent to the experimental tests. Then, each individual's sample was divided into ۲ equal parts: a control group without any intervention and an intervention group whose semen was incubated with tamoxifen. Sperm viability was assessed using trypan blue staining. The results were evaluated using the Mann-Whitney test. Tamoxifen improved sperm viability, but these changes were not significant. The addition of tamoxifen improves sperm viability in patients with oligospermia.

کلیدواژه ها

Oligospermia, Tamoxifen, Viability, Sperm

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