Impact of COVID-۱۹ infection on placental histopathology and maternal-perinatal outcomes: A cross-sectional study
- سال انتشار: 1404
- محل انتشار: International Journal of Reproductive BioMedicine، دوره: 23، شماره: 6
- کد COI اختصاصی: JR_IJRM-23-6_003
- زبان مقاله: انگلیسی
- تعداد مشاهده: 101
نویسندگان
Department of Histology, School of Medicine, Research and Clinical Center for Infertility, Dezful University of Medical Sciences, Dezful, Iran.
Department of Histology, School of Medicine, Dezful University of Medical Sciences, Dezful, Iran.
Department of Biostatistics, School of Medicine, Dezful University of Medical Sciences, Dezful, Iran.
Student Research Committee, Dezful University of Medical Sciences, Dezful, Iran.
Department of Obstetrics and Gynecology, School of Medicine, Research and Clinical Center for Infertility, Dezful University of Medical Sciences, Dezful, Iran.
چکیده
Background: Coronavirus disease ۲۰۱۹ (COVID-۱۹) presents a broad spectrum of clinical outcomes and, unlike other coronaviruses, poses significant risks during pregnancy. A primary concern is the potential for vertical transmission from mother to fetus, affecting both maternal and fetal health. Objective: This study aimed to investigate the placental histopathology and maternal-perinatal outcomes in mothers infected with COVID-۱۹. Materials and Methods: In this cross-sectional study, ۴۰ pregnant women referred to Ganjavian hospital, Dezful, Iran for delivery from June to October ۲۰۲۱ were enrolled in ۲ groups: group I who were women with COVID-۱۹ on the day of delivery (n = ۳۰) and group II who were women without COVID-۱۹ (n = ۱۰). Placental tissue samples were collected post-delivery to assess histopathological changes and placental weight. Additionally, maternal and neonatal characteristics including maternal age, the number of prior deliveries and pregnancies, gestational age, ۱- and ۵-min Apgar scores, and maternal oxygen administration, mode of delivery, and neonatal COVID-۱۹ test results, were compared between the groups. Results: No significant differences were found between the groups regarding maternal age, gestational age, parity, Apgar scores, placental weight, oxygen therapy, or delivery method. However, group I showed significantly higher rates of placental abnormalities such as intravillous fetal thrombosis (p = ۰.۰۰۲), fibrin deposition, lymphocytic infiltration, chorangiosis, edema, intervillous hemorrhage, syncytial node formation, distal villous hypoplasia, and avascular villi (p < ۰.۰۰۱). Conclusion: According to our study, the placental tissue of pregnant women who have been infected with COVID-۱۹ during their third trimester indicates tissue changes that can lead to poor exchanges between mother and fetus.کلیدواژه ها
Pathology, Placenta, Pregnancy, Severe acute respiratory syndrome coronavirus ۲, COVID-۱۹., آسیب شناسی, جفت, بارداری, سندروم حاد تنفسی, کووید ۲۰۱۹.اطلاعات بیشتر در مورد COI
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