Suspected Crimean-Congo Haemorrhagic Fever Re-Infection: A Case Report with Atypical Serological Profile
- سال انتشار: 1404
- محل انتشار: مجله میکروبیولوژی پزشکی و بیماریهای عفونی، دوره: 13، شماره: 2
- کد COI اختصاصی: JR_JOMMID-13-2_010
- زبان مقاله: انگلیسی
- تعداد مشاهده: 17
نویسندگان
Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, Tehran, Iran
Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, Tehran, Iran
Educational and Treatment Centre, Valiasr Hospital, Kerman University of Medical Sciences, Shahrebabak, Iran
WHO Collaborating Center for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran, Iran
Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging Infectious Diseases
Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging Infectious Diseases
Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, Tehran, Iran
Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, Tehran, Iran
Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, Tehran, Iran
Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, Tehran, Iran
Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, Tehran, Iran
Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, Tehran, Iran
Centre of Disease Control (CDC), Ministry of Health, Tehran, Iran
Département de microbiologie-infectiologie et d’immunologie, Université Laval, Quebec City, Quebec, Canada
Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, Tehran, Iran; Research Center for Emerging and Reemerging Infectious Disease, Pasteur Institute of Iran, Tehran, Iran
چکیده
A ۵۳-year-old male farmer presented with clinical manifestations consistent with Crimean-Congo Hemorrhagic Fever (CCHF) virus infection, reporting a recent history of tick bite. To confirm the diagnosis, molecular and serological assays were performed on four specimens collected following the onset of illness. Reverse transcription-polymerase chain reaction (RT-PCR) detected CCHF virus RNA in the initial sample, while serum immunoglobulin M (IgM) antibodies were undetectable in all specimens. Notably, a robust immunoglobulin G (IgG) antibody response was observed across all samples. The concurrence of detectable viral RNA with the presence of IgG antibodies, but the absence of IgM, in the acute phase sample suggests a potential case of CCHF virus re-infection. These findings hold significant implications for public health, particularly regarding our understanding of CCHF virus infection dynamics, diagnostics, and vaccine development strategies.کلیدواژه ها
Crimean-Congo Hemorrhagic Fever, Re-infection, Iran, Case report, RT-PCRاطلاعات بیشتر در مورد COI
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