Moupinamide, Diuvaretin, and Conocarpan as Natural Compounds: Anti-Ovarian and Anti‐Enzymatic Appraisals
- سال انتشار: 1404
- محل انتشار: Iranian Journal of Chemistry and Chemical Engineering، دوره: 44، شماره: 7
- کد COI اختصاصی: JR_IJCCE-44-7_012
- زبان مقاله: انگلیسی
- تعداد مشاهده: 23
نویسندگان
Department of Gynecology, Jingjiang People's Hospital Affiliated to Yangzhou University, Jingjiang, Jiangsu, ۲۱۴۵۰۰, P.R. CHINA
Department of Obstetrics and Gynecology, Huaian Hospital of Huaian City, Huaian, Jiangsu, ۲۲۳۲۰۰, P.R. CHINA
Department of Gynecology, Jingjiang People's Hospital Affiliated to Yangzhou University, Jingjiang, Jiangsu, ۲۱۴۵۰۰, P.R. CHINA
Department of Gynaecology and Obstetrics, The ۹۶۲nd Hospital of the PLA Joint Logistic Support Force, Harbin Heilongjiang, ۱۵۰۰۸۰, P.R. CHINA
چکیده
One of the deadliest gynecological malignancies and the primary cause of cancer-related mortality for women globally is ovarian cancer. Many natural medicines derived from Chinese herbs have been discovered in recent years to have anti-cancer properties both in vitro and in silico. These products have been shown to restrict angiogenesis, limit proliferation, induce apoptosis, delay metastasis, and improve chemotherapy. IC۵۰ values of diuvaretin as the best anti-cancer in this study for ovarian cell lines (NIH-OVCAR-۳, UACC-۱۵۹۸, UWB۱.۲۸۹, ES-۲, TOV-۲۱G) were ۰.۹۱ ± ۰.۰۸, ۱.۲۶ ± ۰.۰۵, ۲.۶۳ ± ۰.۰۸, ۰.۹۴ ± ۰.۰۷, ۰.۲۸ ± ۰.۰۳ µM, respectively. For collagenase enzyme, IC۵۰ values of natural compounds (Moupinamide, diuvaretin, and conocarpan) and standard were ۱۸.۲۴±۲.۴۷, ۷.۵۰ ± ۰.۶۸, and ۳۰.۹۴ ± ۵.۱۱ µM, respectively. Moupinamide, diuvaretin, and conocarpan interactions with collagenase and elastase were assessed through various methodologies, including molecular docking analyses, MM/GBSA calculations, and Molecular Dynamics (MD) simulations. Furthermore, the anti-cancer efficacy of these compounds was evaluated against a range of ovarian cancer cell lines, namely ES-۲, NIH-OVCAR-۳, TOV-۲۱G, UACC-۱۵۹۸, and UWB۱.۲۸۹. The study also investigated the chemical interactions of moupinamide, diuvaretin, and conocarpan with several surface receptor proteins, including the EGFR, Formyl Peptide Receptor–Like ۱, CD۴۴, folate receptor, M۲ muscarinic receptor, and estrogen receptors, utilizing computational methods. The findings indicated notable atomic interactions, highlighting that these compounds established robust associations with the targeted enzymes and receptors. As a result, moupinamide, diuvaretin, and conocarpan can inhibit these enzymes' activity and hinder the proliferation of cancerous cells.کلیدواژه ها
natural compounds, COLLAGENASE, elastase, anti-ovarian, molecular dynamicsاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.