Impact of a ۱۲-week combined strength, aerobic, and balance training program on dopamine and serotonin levels in patients with Parkinson’s disease: a randomized clinical trial
- سال انتشار: 1404
- محل انتشار: مجله دانشگاه علوم پزشکی شهرکرد، دوره: 27، شماره: 2
- کد COI اختصاصی: JR_SKUMS-27-2_006
- زبان مقاله: انگلیسی
- تعداد مشاهده: 53
نویسندگان
چکیده
Background and aims: Serotonin and dopamine are monoamine neurotransmitters that are reduced in Parkinson’s disease) (PD). This study examined the effects of the ۱۲-week combined strength, aerobic, and balance training program on dopamine and serotonin plasma levels in patients with Parkinson’s disease (PD). Methods: This study was designed as a randomized clinical trial. A total of ۳۰ participants were selected using convenience sampling and randomly assigned to one of two groups using block randomization, including a combined exercise group (strength, aerobic, and balance exercises) of ۱۵ participants and a PD group with ۱۵ participants. The study was conducted in ۲۰۲۴ in Isfahan, Iran. The training program lasted ۱۲ weeks, with five weekly sessions held at a sports club. The data were analyzed using ANCOVA for between-group comparisons and a paired test for within-group changes (P< ۰.۰۵). Results: The results revealed significant differences in dopamine and serotonin among the two PD groups (P< ۰.۰۰۱). However, there was a substantial increase in the combined exercise program group compared with the PD group (P< ۰.۰۰۱). In the combined exercise group, dopamine levels increased from ۰.۰۱۴۱±۰.۰۰۳ at the pretest to ۰.۰۸۵۳±۰.۰۳۳ at the posttest (P=۰.۰۰۱). Finally, serotonin levels rose from ۴.۵۹±۰.۵۶ to ۶.۵۹±۰.۹۰ (P=۰.۰۰۱). Conclusion: The combined exercise increased the dopamine and serotonin levels in PD. Accordingly, performing combined exercise can be used as a therapeutic intervention in PD prevention and treatment strategies.کلیدواژه ها
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.