Molecular studies and antioxidant activity of new synthesis of Oxadiozolo (۳,۲-a) Pyrimidine linking to imidazopyridine

سال انتشار: 1404
محل انتشار: مقالات مروری و پژوهشی شیمی، دوره: 8، شماره: 3
کد COI اختصاصی: JR_CHRL-8-3_012
زبان مقاله: انگلیسی
تعداد مشاهده: 33

نویسندگان

Department of chemistry, College of science,Baghdad University, Baghdad Iraq

چکیده

A new oxadiazole (۳,۲-a) pyrimidine connected to imidazopyridine was created in this investigation. The synthesis was accomplished in a series of steps, starting with the formation of ۲-(۴-bromophenyl) imidazo[۱,۲-a] pyridine (A۱) by the reaction of ۲-aminopyridine with ۴-bromophenacyl bromide. The Mannich base (A۲) was then created by reacting compound) A۱( with ۲-aminobenzoic acid in an acidic medium. The next step was to create ۲-amino oxadiazole (A۳) by ring-closing compound )A۲ (with semicarbazide and POCl₃. The Oxadiozolo(۳,۲-a) Pyrimidine derivatives (A۷-A۹) were obtained by reacting the amino group derivative in compound)A۳( with different chalcones in the last step. Additionally, green chemistry techniques without solvents were used to produce molecules (A۲), (A۳), and chalcone derivatives, with positive results. FT-IR spectroscopy, ۱H-NMR, ۱۳CNMR, and mass spectrometry were used to characterize the produced compounds. Additionally, the newly made compounds showed moderate antioxidant activity when tested, and several of them were also put through molecular docking tests.

کلیدواژه ها

Green chemistry, Oxadiozolo (۳, ۲-a) Pyrimidine, Molecular docking, oxadiazole, antioxidants

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