The development of chitosan-salicylic acid crosslinked tripolyphosphate as a pH-sensitive nanocarrier for doxorubicin controlled release
- سال انتشار: 1404
- محل انتشار: مقالات مروری و پژوهشی شیمی، دوره: 8، شماره: 3
- کد COI اختصاصی: JR_CHRL-8-3_015
- زبان مقاله: انگلیسی
- تعداد مشاهده: 50
نویسندگان
Department of Chemistry, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
Department of Chemistry, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
Department of Chemistry, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
Department of Chemistry, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
Polymer Research Laboratory, Department of Chemistry, Faculty of Science, University of Maragheh, ۵۵۱۸۱-۸۳۱۱۱, Maragheh, Iran.
چکیده
Researchers have focused a lot of attention in recent years on using chitosan-based nanocarriers for drug-controlled release to cancer cells. Therefore, in this work, tripolyphosphate (TPP)-crosslinked CS-salicylic acid nanocarriers (CS@SA-DOX-TPP) were created pH-sensitive nanocarriers for the controlled release of doxorubicin (DOX) to the cancer cell. The effective synthesis of nanocarriers is evaluated and validated through various techniques, including FT-IR, XRD, FE-SEM, TEM, DLS, and Zeta potential analysis. The encapsulation efficiency (EE %) of the CS@SA-DOX-TPP was found to be ۸۴.۹ %, respectively. The in vitro drug release analysis confirmed the controlled and pH-sensitive nature of drug release from the synthesized CS@SA-DOX-TPP. The Kosmeyer-Peppas model with Fickian diffusion effectively characterized the release mechanism of DOX. Furthermore, the biocompatibility and safety of the synthesized CS@SA-TPP and greater cytotoxic effects of CS@SA-DOX-TPP against MCF-۷ breast cancer cells confirms by cellular cytotoxicity assy. The results obtained indicate that the developed CS@SA-DOX-TPP may serve as a biocompatible drug delivery system for cancer treatment.کلیدواژه ها
Chitosan, doxorubicin, Nanocarrier, pH-sensitive, Tripolyphosphate, Controlled releaseاطلاعات بیشتر در مورد COI
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