Antioxidant, α-glucosidase inhibitory, and profiling metabolites on Different Parts of Mangrove Sonneratia x urama
- سال انتشار: 1404
- محل انتشار: مقالات مروری و پژوهشی شیمی، دوره: 8، شماره: 3
- کد COI اختصاصی: JR_CHRL-8-3_016
- زبان مقاله: انگلیسی
- تعداد مشاهده: 29
نویسندگان
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Lambung Mangkurat, Banjarbaru, Indonesia
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Lambung Mangkurat, Banjarbaru, Indonesia
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Lambung Mangkurat, Banjarbaru, Indonesia
Department of Agroindustrial Technology, Faculty of Agricultural Technology, Universitas Brawijaya, Malang, Indonesia
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, bandung, Indonesia
Gerontological Nursing Department, Faculty of Nursing, Hasanuddin University. Makassar, Indonesia
Laboratory of Natural Products and Synthetic Chemistry, Department of Chemistry, Faculty of Science and Data Analytics, Institut Teknologi Sepuluh Nopember, Surabaya, Indonesia
Laboratory of Natural Products and Synthetic Chemistry, Department of Chemistry, Faculty of Science and Data Analytics, Institut Teknologi Sepuluh Nopember, Surabaya, Indonesia
چکیده
Sonneratia (Lythraceae), a mangrove plant genus, is a source of metabolites and has been used in traditional medicine. This study investigated the phytochemical content, antioxidant, and α-glucosidase inhibitory activities of different plant parts of Sonneratia x urama extracts and profiled metabolites in the most active extract. The result showed that the fruit, root, and stem bark of S. x urama extract contained high phenolics. The highest total phenolic content (TPC) (۴۶۰.۷۷±۱.۷۱ mgGAE/g dry extract) and total flavonoid contents (TFC) (۱۶.۱۸±۰.۰۸ mgQE/g dry extract) were recorded in stem bark extract compared to other extracts. This extract also showed the highest antioxidant capacity based on DPPH, FRAP, and ABTS methods with ۴۸۳۸.۳۱±۷.۷۷, ۲۵۸۶.۹۵±۳.۲۳, and ۱۹۵۳.۸۳±۱۱.۳۵ µmolTE/g dry extract, respectively. α-glucosidase inhibitory assay showed that the stembark of S. x urama has the highest activity with IC۵۰ ۶۴.۰۷±۷.۲۳ µg/mL. Furthermore, LC-MS/MS was used to profile the metabolites of the stem bark extract. Stem bark extract contained several putative compounds such as ۳,۴’-di-O-methyl ellagic acid, ellagic acid, hallactone B, luteolin ۷-O-glucuronide, ۳,۴-dihydroxy mandelic acid, chelirubine, gallic acid, etc. These findings suggested that the stem bark, fruit, and root of S. x urama can be a potential source of antioxidant and antidiabetic agents.کلیدواژه ها
Sonneratia x urama, Antioxidant, α-glucosidase inhibitory, phenolic, antidiabetesاطلاعات بیشتر در مورد COI
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