Enduring Consequences of Maternal Separation on the Volume of Parvalbumin Interneurons in the Hippocampus

سال انتشار: 1404
محل انتشار: مجله شناخت عصبی تکاملی، دوره: 6، شماره: 1
کد COI اختصاصی: JR_JNCOG-6-1_006
زبان مقاله: انگلیسی
تعداد مشاهده: 35

نویسندگان

Institute for Cognitive and Brain Sciences, Shahid Beheshti University

چکیده

Parvalbumin interneurons (PV-INs) are a subset of GABAergic inhibitory neurons that play a crucial role in regulating cortical and hippocampal circuits. Dysfunction of PV-INs is implicated in neurodevelopmental and psychiatric disorders. Maternal separation (MS) is a well-established rodent paradigm used to study adverse early-life experience and its long-term behavioral effects. MS has been shown to reduce PV-INs expression in different brain regions leading to disrupted cognitive behaviors. This research investigated the long-term effect of the MS on the volume of the PV-INs in the CA۱ subregion of the hippocampus in rats. Male rat pups were separated from their mothers for ۳ hours daily from postnatal day (PND) ۱ to PND ۱۴. After weaning, the animals were maintained in a standard manner until adolescence. At adolescence, brain samples were extracted and the volume of the PV-INs in the CA۱ area of the hippocampus was measured using the ۳D stereological technique with nucleator method. The results showed that the volume of the PV-INs in the CA۱ subregion of the hippocampus in maternally separated rats was significantly smaller (p < ۰.۰۵) than the intact rats in adolescence. This study showed that early life adverse experiences can have a persistent effect on the volume of PV-INs in the hippocampus into adolescence and suggests that MS may lead to a disruption of synaptic excitatory inhibitory balance and may be associated with symptoms related to autistic behaviors resulting from MS that have been reported in previous studies.

کلیدواژه ها

Parvalbumin interneurons volume, Maternal Separation, animal model, neurodevelopmental disorders

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.