Simultaneous Determination of Hydrochlorothiazide and Enalapril Maleate in Pharmaceutical Formulations Using Fourier Transform Infrared Spectrometry
- سال انتشار: 1393
- محل انتشار: Iranian Journal of Chemistry and Chemical Engineering، دوره: 33، شماره: 4
- کد COI اختصاصی: JR_IJCCE-33-4_007
- زبان مقاله: انگلیسی
- تعداد مشاهده: 48
نویسندگان
Chemistry and Chemical Engineering Research Center of Iran, Tehran, I.R. IRAN
Department of Chemistry, Emam Ali University, Tehran, I.R. IRAN
Department of Chemistry, Emam Ali University, Tehran, I.R. IRAN
Department of Chemistry, Arak University, Arak, I.R. IRAN
چکیده
A new Fourier Transform-Infra Red (FT-IR) spectrometric method was developed for assaying hydrochlorothiazide (HCT) and enalapril maleate (ENM) in binary solid pharmaceutical formulations. Multivariate Partial Least Squares (PLS) method was used for calibration of derivative spectral data. Acetonitrile was used as solvent due to its spectral transparency and adequate solubility of analytes in it. A ۴- levels full factorial design of binary standard solutions of HCT and ENM were prepared and used for calibration in the spectral range of ۱۵۵۰-۱۸۰۰ cm-۱. Statistical parameters such as correlation coefficient(R), Standard Error of Estimation (SEE), Standard Error of Prediction (SEP), and Standard Error of Cross Validation (SECV) have been evaluated and used for selecting of optimizing of parameters. Correlation coefficients were ۰.۹۹۹۰ and ۰.۹۹۹۵ and Relative Standard Deviation (RSD) were ۱.۹۷% and ۱.۳۵% (n=۵) for HCT and ENM, respectively. Detection limits of ENM and HCT were obtained ۰.۵۴ and ۰.۹۹ mg/mL respectively. The proposed methods were successfully applied to the determination of the over mentioned drugs in laboratory-prepared mixtures and in commercial tablets. This method has suitable accuracy, precision, repeatability and is comparable with reference standard methods.کلیدواژه ها
FT-IR, Pharmaceutical formulation, Simultaneous determination, Quantitative analysis, Hydrochlorothiazide, Enalapril maleateاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.