One-Step Synthesis of Bovine Serum Albumin Nanoparticles by Hydrothermal Green Treatment
- سال انتشار: 1402
- محل انتشار: Iranian Journal of Chemistry and Chemical Engineering، دوره: 42، شماره: 6
- کد COI اختصاصی: JR_IJCCE-42-6_001
- زبان مقاله: انگلیسی
- تعداد مشاهده: 61
نویسندگان
Department of Chemical & Environmental Engineering, Faculty of Engineering, University of Putra Malaysia, Selangor, ۴۳۴۰۰, MALAYSIA
Department of Chemical & Environmental Engineering, Faculty of Engineering, University of Putra Malaysia, Selangor, ۴۳۴۰۰, MALAYSIA
Department of Chemistry, Faculty of Science, University of Malaysia, Kuala Lumpur, MALAYSIA
New Technologies Research Center, Amirkabir University of Technology, Tehran Polytechnic, P.O. Box ۱۵۸۷۵-۴۴۱۳ Tehran, I.R. IRAN
Department of Chemical & Environmental Engineering, Faculty of Engineering, University of Putra Malaysia, Selangor, ۴۳۴۰۰, MALAYSIA
چکیده
The non-toxic BSA-based NanoParticles (NPs) are developed without any additives with hydrothermal SubCritical Water Treatment (SCWT). The optimum BSA-based NPs are gained by applying Response Surface Methodology (RSM) based on particle size, zeta potential, and polydispersity. The SCWT conditions are optimized in terms of these three dependent variables, which have significant impacts on the BSA-based NPs application. The optimum BSA-based NPs prepared with ۲.۷۳% (w/v) of initial BSA solution concentration, the lowest initial concentration that is used to synthesize BSA-based NPs by now. The SCWT condition of ۱۷۳ °C and ۲.۰۷ min of SCWT holding time shows that the zeta potential of -۳۸.۸۷ mV with the finest particle size and PI (۱۴۷.۳۲ nm and ۰.۲۴, respectively) is the optimized composition. The fabricated BSA-based NPs are characterized by the UV-vis, screening electron microscope (SEM), and stability assessment study.کلیدواژه ها
Bovine serum albumin, Nanoparticle, Hydrothermal, Optimization, subcritical water treatment, green recovery, blood waste, Drug Delivery, Response surface methodologyاطلاعات بیشتر در مورد COI
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