Introduction:
Chronic infections significantly impair diabetic foot wound healing. Diabetic wounds are more susceptible to sustained bacterial infections, particularly Staphylococcus aureus, leading to delayed healing compared to non-diabetic wounds. The most common type of infection in diabetic patients is
diabetic foot ulcer (DFU), which is followed by the first organ that leads to amputation in ۴۰-۷۰% of The aim of this study is to investigate diabetic ulcers and chronic and long-term tissue infections in these patients and to investigate the relationship between the two in order to prevent irreversible damage to patients and even human societies with awareness and health policy planning. Methods: A review was performed independently by two people based on the PICO criteria aligned to the research objective and based on the PRISMA checklist. Articles were searched in PubMed, CINAHL, Medline, Web of Science, SID databases Google Scholar search engine, and operators. The time limit between ۲۰۱۸ and ۲۰۲۳. was determined using the MESH keywords “Chronic infections”, “diabetic foot ulcer” and “healing process”. After checking the entry and exit criteria and critically evaluating the quality of the selected articles, a total of ۹ articles were included in the study. Results: The results of the studies show that the delay in the
healing process of diabetic wounds is influenced by infectious microbes and fungi that grow inside the protective biofilms. These structures often lead to chronic infections and require antimicrobial intervention to accelerate the healing process. Biofilm formation is an important pathophysiological step in DFU, which plays a key role in disease progression, chronicity of the lesion, antibiotic resistance, and difficulty in wound healing. In the present study, infected diabetic wounds and factors associated with chronic infections, such as alterations in the osmolarity of substances and ions, oxidative stress, changes in cellular phenotype, vasculopathy, neuropathy, and other factors leading to infections and chronic inflammations, were examined. Conclusion: As a result of the studies conducted in connection with the subject, it is stated that
