Effects of Vitamin E on Electrocardiographic Parameters of Broiler Chickens With Pulmonary Hypertension
- سال انتشار: 1404
- محل انتشار: فصلنامه طب دامی ایران، دوره: 19، شماره: 2
- کد COI اختصاصی: JR_IJVM-19-2_014
- زبان مقاله: انگلیسی
- تعداد مشاهده: 93
نویسندگان
Department of Biology, Faculty of Basic Science, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
Department of Basic Sciences, Faculty of Veterinary Medicine, Garmsar Branch, Islamic Azad University, Garmsar, Iran.
Department of Basic Sciences, Faculty of Veterinary Medicine, Garmsar Branch, Islamic Azad University, Garmsar, Iran.
چکیده
Background: Pulmonary hypertension in broiler chickens is a multifactorial syndrome leading to significant mortality, primarily due to hypoxemia and cardiac overload.Objectives: This study aimed to assess the impact of vitamin E supplementation on electrocardiographic parameters in broiler chickens subjected to triiodothyronine (T۳)-induced pulmonary hypertension.Methods: A total of ۱۸۰ chicks were randomly assigned to four groups: One control and three treatment groups. The chicks in the treatment groups received vitamin E (α-tocopherol) at doses of ۱۰۰, ۲۰۰, and ۴۰۰ IU from one day to ۴۹ days of age. To induce pulmonary hypertension, all chicks were administered ۱.۵ mg/kg of T۳ from the seventh day to the end of the experiment through their diet. Electrocardiograms were recorded at ۱۴ and ۴۹ days of age, and right ventricular hypertrophy (RVH) was assessed post-euthanasia. Results: Significant decreases in the right ventricle/ total ventricle weight (RV/TV) ratio were observed in the treated groups on day ۴۹ (P< ۰.۰۵). Electrocardiographic analysis revealed reductions in S, T, and R wave amplitudes specifically on day ۴۹ for all vitamin E doses (P< ۰.۰۵). The QRS interval significantly increased at all doses on day ۴۹, while the RR interval increased at certain doses on days ۱۴ and ۴۹ compared to the control group (P< ۰.۰۵). Conclusion: Vitamin E supplementation effectively modulates the induction of pulmonary hypertension and associated ventricular hypertrophy in broiler chickens.کلیدواژه ها
Broiler Chickens, Electrocardiographic Parameters, pulmonary hypertension, Triiodothyronine (T۳), vitamin Eاطلاعات بیشتر در مورد COI
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