۸-week Aerobic Exercise and Vitamin D Supplementation: Impact on Hypertension With Vitamin D Deficiency

Background: This research aims to investigate the performance of ۸ weeks of aerobic exercise and vitamin D supplementation on nitric oxide (NO) and endothelin ۱ (ET-۱) indicators in patients with high blood pressure and vitamin D deficiency. Materials and Methods: In this quasi-experimental research, ۴۰ qualified men and women were randomly divided into four groups (supplement group, placebo + exercise group, supplement + exercise group, and control group). The training program of the experimental groups included ۸ weeks of aerobic exercise running on a treadmill (۳ sessions per week). Two groups (exercise + supplement and supplement group) received vitamin D supplement daily in the amount of ۲۰۰۰ international units in a double-blind manner, and the exercise + placebo group received a placebo capsule containing maltodextrin daily. Blood sampling was done to evaluate biochemical variables ۴۸ hours before and after the intervention in a fasting state. Results: The research results show that after ۸ weeks of aerobic training with vitamin D supplementation, there was no significant effect on body mass index, NO, triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), vitamin D, and weight (P<۰.۰۵), but the effects were significant on ET-۱ level and systolic blood pressure which changed in the supplement, supplement+exercise, and exercise+placebo groups compared to the control group (P<۰.۰۵). Also, the vitamin D increase showed a significant change (P<۰.۰۵). Conclusion: Based on the results of the present study, taking vitamin D supplements for ۸ weeks along with aerobic activity reduces ET-۱, increases NO, and improves blood pressure in hypertensive people with vitamin D deficiencies.

کلیدواژه ها:

Vitamin D deficiency ، Nitric oxide (NO) ، Endothelin ۱ (ET-۱) ، Aerobic exercise ، High blood pressure ، Vitamin D