A New Insight Into Salinomycin
- سال انتشار: 1404
- محل انتشار: فصلنامه طب دامی ایران، دوره: 19، شماره: 1
- کد COI اختصاصی: JR_IJVM-19-1_001
- زبان مقاله: انگلیسی
- تعداد مشاهده: 105
نویسندگان
Department of Veterinary Basic Sciences, Faculty of Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Department of Clinical Sciences, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Department of Veterinary Basic Sciences, Faculty of Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Department of Basic Sciences, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran.
چکیده
Salinomycin is a polyether ionophore antibiotic used as a coccidiostat and growth promoter in veterinary medicine and animal husbandry since the ۱۹۸۰s. It is a promising anticancer drug that targets human cancer stem cells and inhibits tumor cell growth. It can induce autophagy, mitophagy, and mitochondrial polarity in cancer cells. Salinomycin can induce cytotoxicity in cancer cells by generating reactive oxygen species and inhibiting cyclooxygenase-۲ activity. It is also lipid-soluble, which can induce toxicity in humans and various animal species, including bovines, sheep, swine, equines, dogs, and birds. Accidental ingestion of high amounts of salinomycin can lead to cardiac toxicity, neural dysfunction, and paralysis in animals. It can also cause liver damage in animals. Studies have shown that different doses of oral salinomycin alter oxidative stress biomarkers, leading to increased inflammatory biomarkers. Treatment for salinomycin toxicosis often involves supportive care and symptomatic therapy. It is crucial to be cautious when using salinomycin, as it can cause harmful side effects due to its severe toxicity.کلیدواژه ها
Anticancer drugs, Coccidiostat, Ionophores, Salinomycin, Toxicosisاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.