Effect of Intra-Operative Topical ۵-Fluorouracil Post-Functional Endoscopic Sinus Surgery: A Randomized Controlled Trial
- سال انتشار: 1404
- محل انتشار: مجله علمی گوش و حلق و بینی ایران، دوره: 37، شماره: 2
- کد COI اختصاصی: JR_IJOTO-37-2_001
- زبان مقاله: انگلیسی
- تعداد مشاهده: 80
نویسندگان
Senior Resident, Department of Otorhinolaryngology, Shri Sathya Sai Medical College and Research Institute, Tamil Nadu.
Professor, Department of ENT and Head and Neck Surgery, Sri Ramachandra University, Tamil Nadu.
Consultant, Department of ENT and Head and Neck Surgery, Apollo Hospitals, Chennai, Tamil Nadu.
چکیده
Introduction: Endoscopic nasal surgery has numerous potential adverse effects, adhesions are at the top of the list. ۵-fluorouracil (۵-FU), which is an analogue of pyrimidine, is utilized in a wide variety of areas for the purpose of preventing adhesions. In the present investigation, our purpose was to analyze the impact of intra-operative application of ۵-flurouracil in the nasal cavity following FESS, as well as to evaluate both subjective and objective outcomes. Materials and Methods: Following the acquisition of institutional ethical approval, a testing procedure that was randomized, prospective, and double-blinded was carried out. After the FESS, a cotton swab soaked in ۱ mL of ۵-flurouracil at ۵ mg/mL was inserted in one side of the nasal cavity and a saline-soaked one in the other. Both of these swabs were kept in place for a period of five minutes. Postoperatively, patients were assessed over ۶ months duration, wherein, adhesions, discharge, crustation, edema and polypoidal changes were analyzed. Subjective symptoms such as nasal block, nasal discharge and loss of smell were also assessed. Results: At the one-week follow-up, the test group had a significantly higher incidence of adhesions (۳۲% vs. ۱۱.۷۶%, respectively) (p = ۰.۰۰۴) than the control group. Mucosal edema, crusting, polypoidal change and nasal discharge continued to significantly diminish in both groups. Furthermore, improvement in smell perception in the test group at the ۲۰th week post-operatively was statistically significant (p= ۰.۰۱۴). Conclusions: Adhesions are less common in the early postoperative period in individuals who underwent FESS with or without polypectomy when ۵-FU is administered topically. There is also an improvement in smell perception with a reduction of mucosal edema, crusting, polypoidal change and nasal discharge enabling better healing.کلیدواژه ها
randomized control trial, Functional Endoscopic Sinus surgery, outcomes, ۵-fluorouracil, Adhesions, Synechiaاطلاعات بیشتر در مورد COI
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