Thymoquinone attenuates paw incision-induced spontaneous and evoked pain through anti-oxidative and anti-inflammatory mechanisms in rats
- سال انتشار: 1404
- محل انتشار: گفتمان پژوهش دامپزشکی، دوره: 16، شماره: 2
- کد COI اختصاصی: JR_VRFAN-16-2_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 91
نویسندگان
DVSc Candidate, Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
چکیده
Surgery commonly causes post-operative pain that should be alleviated to prevent complications. In addition to the use of synthetic drugs, there has been a widespread desire to use medicinal plants for surgical pain management. Thymoquinone (TQ), a constituent of Nigella sativa black seeds, exhibits a potent anti-oxidant property. Celecoxib (CLX), a potent non-steroidal anti-inflammatory drug, is widely used in pain management. In the present study, the effects of TQ and CLX on pain caused by hind paw surgical incision were compared. Fifty-six rats were divided into four groups of ۱۴ rats as intact, vehicle, TQ, and CLX groups. In each group, six rats were planned to record pain-related behaviors on days ۱ - ۱۰ and eight rats were designed for determination of serum biochemical alterations on days ۱ (four rats) and ۳ (four rats) after surgery. Oral administrations of TQ and CLX at a same dose of ۱۰.۰۰ mg kg-۱ alleviated paw lifting number (spontaneous pain) and paw withdrawal threshold evoked by von Frey filaments on metal mesh floor, improved the decreased contents of serum total anti-oxidant capacity and superoxide dismutase, and restored the increased levels of serum malondialdehyde and tumor necrosis factor-alpha. The results suggested that TQ by employing anti-oxidant and anti-inflammatory mechanisms, might relieve the pain induced by hind paw plantar incision, being comparable with CLX.کلیدواژه ها
Celecoxib, Incision, Pain, Rats, Thymoquinoneاطلاعات بیشتر در مورد COI
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