Assessment of Hearing Ability in Patients after Head and Neck Cancer Radiotherapy
- سال انتشار: 1403
- محل انتشار: مجله فیزیک پزشکی ایران، دوره: 21، شماره: 5
- کد COI اختصاصی: JR_IJMP-21-5_008
- زبان مقاله: انگلیسی
- تعداد مشاهده: 111
نویسندگان
Students Research Committee, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Students Research Committee, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Department of Radiation Oncology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Associate Professor in Medical Physics, Department of Medical Physics, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
چکیده
Introduction: The study assesses radiation-induced sensorineural hearing loss (SNHL) in head and neck cancer patients, highlighting the common occurrence of SNHL as a significant side effect of radiation therapy (RT) targeting the cochlea and acoustic pathways. Material and Methods: The study included ۳۴ patients (۲۲ men, ۱۲ women, mean age ۴۰.۱۳ ± ۲۶.۸ years) with head and neck cancers undergoing three-dimensional conformal radiation therapy (۳D-CRT); ۱۶ also had chemoradiotherapy (CRT). Pure-tone audiometry (PTA: ۲۵۰-۸۰۰۰ Hz) was done before, immediately after, and three months post-RT for all patients. Hearing impairment was evaluated using the CTCAE ۴.۰۳ scoring system. Results: According to the findings, ۱۹% and ۳۷% of ears experienced SNHL immediately post-RT and ۳ months after RT, respectively. The mean cochlear dose was ۲۵.۴۸ ± ۱۳.۵۶ Gy. A significant correlation existed between the cochlear dose and SNHL incidence (P-value < ۰.۰۵). Regression analysis indicated the mean cochlear dose as a robust predictor of SNHL, particularly at ۸۰۰۰ Hz (β = ۰.۵۷۰, P-value = ۰.۰۰۰۱). Highest SNHL incidence at ۸۰۰۰ Hz, ۳ months post-RT. A significant difference in SNHL threshold was observed between men and women at the frequency of ۱۰۰۰ Hz (P-value = ۰.۰۲۴). There was a statistically significant difference in SNHL thresholds between patients who underwent CRT versus those treated with RT alone (P-value < ۰.۰۵). Conclusion: RT commonly causes SNHL in head and neck cancer patients. Mean cochlear dose predicts SNHL, especially at higher frequencies.کلیدواژه ها
Head And Neck Cancer, Radiation Therapy, Sensorineural hearing loss, Audiometry, Side effectsاطلاعات بیشتر در مورد COI
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