Improvement of image quality for small lesion sizes in ۱۸F-FDG prone breast silicon photomultiplier-based PET/CT imaging
- سال انتشار: 1404
- محل انتشار: مجله پزشکی هسته ای و زیست شناسی آسیا اقیانوسیه، دوره: 13، شماره: 1
- کد COI اختصاصی: JR_JNMB-13-1_009
- زبان مقاله: انگلیسی
- تعداد مشاهده: 9
نویسندگان
Department of Radiology, Shimane University Hospital, Izumo, Japan
Department of Radiology, Faculty of Medicine, Shimane University, Izumo, Japan
Division of Medical Informatics, Shimane University Hospital, Izumo, Japan
Department of Radiology, Shimane University Hospital, Izumo, Japan
Department of Radiology, Shimane University Hospital, Izumo, Japan
Department of Radiology, Faculty of Medicine, Shimane University, Izumo, Japan
Department of Radiology, Faculty of Medicine, Shimane University, Izumo, Japan
چکیده
Objective(s): We investigated image quality and standardized uptake values (SUVs) for different lesion sizes using clinical data generated by ۱۸F-FDG-prone breast silicon photomultiplier (SiPM)-based positron emission tomography/computed tomography (PET/CT).Methods: We evaluated the effect of point-spread function (PSF) modeling and Gaussian filtering (Gau) and determined the optimal reconstruction conditions. We compared the signal-to-noise ratio (SNR), contrast, %coefficient of variation (%CV), SUV, and Likert scale score between ordered-subset expectation maximization (OSEM) time-of-flight (TOF) and OSEM+TOF+PSF in phantom and clinical studies. The conventional image was generated with OSEM+TOF_Gau ۶ mm. The National Electrical Manufacturers Association body phantom with ۱۰-mm hot sphere data was acquired for ۵ min. Twenty-six patients (۴۰ lesions, ranging from ۳.۷ to ۶۳.۰ mm) were examined using prone breast PET/CT with a breast positioner for breast cancer staging. PET data were acquired ۱۲۵±۹.۷ min after intravenous injection of ۲۲۰±۱۶.۱ MBq at ۵ min/bed.Results: In the phantom study, a high SNR was obtained from a ۳- to ۵-mm Gaussian filter for OSEM+TOF+PSF. The contrast obtained with OSEM+TOF without Gaussian filtering was superior to that obtained with OSEM+TOF+PSF_Gau ۴ mm. In the clinical study, the image quality depended on lesion size. The average SNR was significantly higher at ۴۰.۸% for lesions > ۲۰ mm with OSEM+TOF_Gau ۶ mm than with OSEM+TOF without Gaussian filtering. The average contrast for lesions ≤۱۰ mm was significantly higher by ۴۲.۰% with OSEM+TOF without Gaussian filtering than with OSEM+TOF_Gau ۶ mm. The average SUVmax of OSEM+TOF without Gaussian filtering significantly increased by ۵۳.۳% for lesions ≤۱۰ mm.Conclusion: OSEM+TOF without Gaussian filtering provided good contrast and quantitative value for small lesions.کلیدواژه ها
Breast Cancer, Digital PET, Prone positionاطلاعات بیشتر در مورد COI
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