The Effect of High-Intensity Interval Training in the Presence of L-Carnitine on the Expression of MCT۱, PGC-۱, and CS in the Liver of Male Wistar Rats

  • سال انتشار: 1403
  • محل انتشار: مجله دانشگاه علوم پزشکی کرمان، دوره: 31، شماره: 5
  • کد COI اختصاصی: JR_JKMU-31-5_003
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 4
دانلود فایل این مقاله

نویسندگان

Mahdiyeh Haj Hosseini

Department of Physical Education and Sport Science,National University of Skills(NS),Tehran, Iran

Beydolah Shahouzehi

Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

Najmeh Sadat Hosseini

Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

چکیده

Background: T Liver oxidative metabolism disorder is dependent on several factors that lead to liver diseases like non-alcoholic fatty liver disease. Our hypothesis was that the combination of high-intensity interval training (HIIT) and L-carnitine affects the expression of citrate synthase (CS), PGC-۱α, and monocarboxylate transporter ۱ (MCT۱) in the liver of male Wistar rats.Methods: Thirty-two male Wistar rats were divided into four groups (n=۸): control, L-carnitine (۲۰۰ mg/kg/d, four weeks, IP), HIIT, and HIIT+L-carnitine (۲۰۰ mg/kg/d, four weeks, IP). HIIT training was performed for four weeks (five days a week); then, the animals were anesthetized, and their liver tissues were extracted for real-time PCR to measure MCT۱, PGC-۱α, and CS. SPSS ۲۲ software was used to analyze the data obtained in different groups, with P< ۰.۰۵ considered statistically significant.Results: MCT۱ expression significantly increased in the HIIT and HIIT+L-carnitine groups compared to the control group (P< ۰.۰۰۱). PGC- ۱α expression significantly increased in the HIIT+L-carnitine group compared to the control and L-carnitine groups (P< ۰.۰۰۱). Also, PGC- ۱α expression significantly increased in the HIIT group compared to the control group (P< ۰.۰۰۱). Furthermore, CS expression significantly increased in all groups compared to the control group (P< ۰.۰۰۱).Conclusion: HIIT exercise combined with L-carnitine supplementation increases the expression of MCT۱, PGC-۱α, and CS in the liver. Therefore, it seems that performing HIIT exercises and taking L-carnitine supplements can prevent the consequences of fat accumulation in the liver.

کلیدواژه ها

high-intensity interval training, MCT۱, PGC-۱α, CS gene

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.