A clean and efficient one-pot three-component synthesis of novel dihydropyrido[2,3-d]pyrimidines

An efficient classical–assisted preparation of a series of novel 5-aryl-2-(ethylthio)-5,6- dihyridopyrido[2,3-d] pyrimidine-4,7(3H,8H)-diones via the reaction of 6-amino-2-(ethylthio)-pyrimidine- 4(3H)-one, Meldrum’s acid and various arylaldehydes using one-pot three-component approach is described. This rapid method producedthe products in short reaction times (180-200 min) and excellent yields (72-80%).

کلیدواژه ها:

6-amino-2-(ethylthio)-pyrimidine-4(3H)-one ، pyrido [2 ، 3-d] pyrimidine ، Meldrum’s acid ، one-pot reaction ، Multi-component reactions