Topical Nigella Sativa oil versus diclofenac gel for knee osteoarthritis: A randomized open-labeled active-controlled clinical trial
- سال انتشار: 1403
- محل انتشار: فصلنامه تحقیقات روماتولوژی، دوره: 9، شماره: 4
- کد COI اختصاصی: JR_RHRE-9-4_001
- زبان مقاله: انگلیسی
- تعداد مشاهده: 122
نویسندگان
Department of internal medicine, Ali Ebn Abitaleb Hospital, Zahedan University of Medical sciences, Zahedan, Iran
Department of community medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Department of Pharmacology, Zahedan University of Medical Sciences, Zahedan pharmacology Research Center, Zahedan, Iran
Department of Internal Medicine, Ali Ebne Abitaleb Hospital, Zahedan University of Medical Sciences, Zahedan, Iran
چکیده
Osteoarthritis (OA) is the most common cause of pain and disability among older adults. This study aims to compare the effect of topical use of Nigella Sativa (NS) oil and diclofenac gel on pain and function in knee OA (KOA). This randomized clinical trial was performed in a rheumatology clinic. Patients who fulfilled the American College of Rheumatology criteria for OA were selected. The subjects were randomly assigned to apply NS oil or diclofenac gel on the knee joint ۴ times a day for ۳ weeks. The outcomes, including pain and physical activity, were measured with a visual analog scale and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Of the initial ۲۰۰ KOA patients who were assessed for eligibility, data from ۶۰ patients (۳۰ in each group) were analyzed. The two groups had no significant difference regarding age, sex, and body mass index. Both interventions showed statistically significant within-group differences in terms of the WOMAC subscales of pain, stiffness, function and VAS of pain (P < ۰.۰۰۱). However, there was no significant difference between the groups. Our findings suggested that topical use of NS oil could be as effective as diclofenac gel in reducing pain and stiffness and improving function in KOA.کلیدواژه ها
Nigella sativa, Black Seed, osteoarthritis, complementary therapyاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.