The Role of Neutrophils Extracellular Traps in Autoimmune Diseases
- سال انتشار: 1403
- محل انتشار: مجله اقدامات و تحقیقات بیمارستانی، دوره: 9، شماره: 1
- کد COI اختصاصی: JR_HPR-9-1_001
- زبان مقاله: انگلیسی
- تعداد مشاهده: 112
نویسندگان
Department of Veterinary Sciences, Shabestar Branch, Islamic Azad University, Shabestar, Iran
Department of Veterinary Sciences, Shabestar Branch, Islamic Azad University, Shabestar, Iran
Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
Students Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran
Students Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran
Hadi Esmaeili Ghouvarchinghaleh
Applied Virology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical sciences, Tehran, Iran
چکیده
Some neutrophils are shown to be able to release structures consisting of DNA strands associated with histones, decorated with about ۲۰ proteins. These structures are called Neutrophil Extracellular Traps (NETs). NETosis is the process by which the formation of neutrophil extracellular traps eventually leads to cell death. Indeed, NETosis is a cell death process that is unique from other common types of cell death. Two kinds of NETosis have been identified, vital NETosis and suicidal NETosis. Vital NETosis, unlike suicidal NETosis, occurs a few minutes after neutrophil stimulation. Suicidal NETosis can be dependent on or independent of NADPH oxidase. NADPH-independent NETosis can be induced by calcium ionophores. As long as NETs are set up properly, they play an important role in fighting infections. However, if not properly adjusted, tissue damage and inflammation increase. Furthermore, NETs are involved in some autoimmune diseases.کلیدواژه ها
Neutrophils, NETosis, autoimmune, Neutrophil extracellular traps, NETsاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.