In silico evidence for the efficacy of egg peptides in type ۲ diabetes treatment

سال انتشار: 1402
محل انتشار: دوازدهمین همایش ملی و سومین همایش بین المللی بیوانفورماتیک
کد COI اختصاصی: IBIS12_098
زبان مقاله: انگلیسی
تعداد مشاهده: 84

نویسندگان

Faculty of Sciences and Advanced Technologies in Biology, University of Science and Culture, Tehran, Iran

Department of Endocrinology and Female Infertility at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran- Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Repro

Maryam Shahhosseini

Reproductive Epidemiology Research Center, Royan Institute for Reproductive, Biomedicine, ACECR, Tehran, Iran- Department of Basic and Population Based Studies in NCD, Reproductive Epidemiology Research Center, Royan Institute, ACECR, Tehran, Iran- Depart

چکیده

Type ۲ diabetes is a chronic and prevalent disease that is associated with increased bloodglucose levels and insulin resistance. A large percentage of people in society are susceptible to thisdisease. In this disease, inflammatory cytokines such as TNF- play a crucial role in a large number ofinflammatory processes in the body, because increased levels of TNF- lead to inflammation and insulinresistance, which is one of the prominent features of type ۲ diabetes. Scientific evidence shows thatproteins found in egg whites may have a modulating effect on diabetes. Based on this, the aim of thisstudy was to investigate the effectiveness of egg peptides in inhibiting TNF- using computationalmethods. Based on this, the main egg proteins were extracted from the Uniprot database and convertedinto ۱۵-amino acid peptides using the Genscript database. Subsequently, the Pepcalc and Expasydatabases were utilized for screening based on the charge, solubility and stability of the peptides.Finally, we reached ۴۵% of the egg peptides that were able to pass these three stages of screening. Thepeptides obtained from the screening were evaluated for docking with TNF_ using Hpepdocksoftware. The docking results revealed that ۴۰% of the peptides obtained from the main egg proteinshad stability, favorable solubility and suitable binding energy with G less than -۲۰۰ KJ/mol. Ourcomputational results showed for the first time that the peptides in egg may have the potential to inhibitTNF- and may be effective in reducing insulin resistance and modulating diabetes. This study presentsnovel insights, indicating that peptides derived from egg proteins may have the potential to modulateTNF-α, highlighting a promising direction for further research in the treatment and control of type ۲diabetes.

کلیدواژه ها

type ۲ diabetes , egg peptides , TNF_ alpha , Computational methods

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