A Molecular Dynamics Simulation Study on Drug-Loaded Thermo-Responsive Micelles Based on PNIPAAM-b-PLA Copolymers ThroughMicrofludic and Bulk Methods
- سال انتشار: 1403
- محل انتشار: شانزدهمین سمینار بین المللی علوم و تکنولوژی پلیمر (ISPST ۲۰۲۴)
- کد COI اختصاصی: ISPST16_621
- زبان مقاله: انگلیسی
- تعداد مشاهده: 94
نویسندگان
Nano-Biopolymers Research Laboratory, School of Chemical Engineering, College of Engineering, Universityof Tehran, Tehran, Iran
Nano-Biopolymers Research Laboratory, School of Chemical Engineering, College of Engineering, Universityof Tehran, Tehran, Iran
Nano-Biopolymers Research Laboratory, School of Chemical Engineering, College of Engineering, Universityof Tehran, Tehran, Iran
Nano-Biopolymers Research Laboratory, School of Chemical Engineering, College of Engineering, Universityof Tehran, Tehran, Iran
چکیده
In this study, the effects of self-assembly on polymeric micelles using the microfluidic (MF)technique, and temperature on their size and compactness were investigated and compared with bulkmethod. Additionally, the drug release behavior of docetaxel (DTX)-loaded micelles was studied toachieve controlled and targeted drug delivery systems in cancer therapy via all-atom moleculardynamics simulations. In this regard, the self-assembly of thermo-responsive micelles, based on poly(N-isopropylacrylamide-b-lauryl acrylate) copolymer was simulated at three temperatures byemploying two different approaches, involving MF and bulk. The simulation results, comprising theradius of gyration and mean-square displacement, showed efficient DTX loading and releaseperformance through MF technique.کلیدواژه ها
Molecular dynamics, Micelle, Self-assembly, Microfluidic, Thermo-responsiveness,Drug deliveryاطلاعات بیشتر در مورد COI
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