An Investigation on Click Chemistry-based Gelation of CarboxymethylChitosan Sulfate/Oxidized Alginate Injectable Hydrogel
- سال انتشار: 1403
- محل انتشار: شانزدهمین سمینار بین المللی علوم و تکنولوژی پلیمر (ISPST ۲۰۲۴)
- کد COI اختصاصی: ISPST16_461
- زبان مقاله: انگلیسی
- تعداد مشاهده: 212
نویسندگان
Department of Polymer Engineering, Amirkabir University of Technology, P.O. Box ۱۵۸۷۵-۴۴۱۳, Tehran, Iran.
Department of Polymer Engineering, Amirkabir University of Technology, P.O. Box ۱۵۸۷۵-۴۴۱۳, Tehran, Iran.
Department of Polymer Engineering, Amirkabir University of Technology, P.O. Box ۱۵۸۷۵-۴۴۱۳, Tehran, Iran.
Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Disease ResearchInstitute, Tehran Heart Center Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine,Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Polymer Engineering, Amirkabir University of Technology, P.O. Box ۱۵۸۷۵-۴۴۱۳, Tehran, Iran.
چکیده
Myocardial infarction (MI) leads to massive cardiomyocyte death and deposition of collagen fibers.Current treatments have limitations, but injectable hydrogel has emerged as a promising method forin situ repair-infracted cardiac tissue. In this study, we prepared an injectable biomimetic hydrogel totreat infarcted tissue. The hydrogel was prepared via a Schiff-base reaction of oxidized alginate (OA)and carboxymethyl chitosan sulfate (CMCS) with angiogenesis function. The presence of sulfategroups in the hydrogel, in addition to its anticoagulant properties, binds specific proteins, includinggrowth factors, and regulates their release. The resulting hydrogels were characterized by FTIR andSEM, and gelation time and self-healing were investigatedکلیدواژه ها
Biopolymer, Injectable hydrogel, Schiff-base, Dynamic covalent, Myocardial infractionاطلاعات بیشتر در مورد COI
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